REACH(1) entered into force in June 2007 and has hence been operational for six years. With the first registration deadline in November 2010, the European Chemicals Agency (ECHA(2)) has received a large amount of scientific and administrative information related to chemical substances. In order to understand what type of data on ecotoxicity endpoints was submitted under the REACH framework a detailed analysis of the availability and content of relevant information was performed. To avoid unnecessary testing, the REACH Regulation provides registrants with the possibility to build testing strategies and to adopt the standard information requirements based on the specific conditions listed in the regulation. The types of information submitted by registrants to fulfil data requirements for aquatic, sediment and terrestrial toxicity endpoints were analysed. The REACH database analysis confirms large differences in the availability of experimental aquatic versus sediment and soil ecotoxicity data. Information requirements on aquatic organisms are mainly covered by experimental data, while those for sediment and soil are mostly waived.
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http://dx.doi.org/10.1016/j.scitotenv.2013.10.074 | DOI Listing |
Environ Toxicol Chem
January 2025
School of Environmental Science and Engineering, Nanjing University of Information Science and Technology, Nanjing, PR China.
In silico methods are increasingly important in predicting the ecotoxicity of engineered nanomaterials (ENMs), encompassing both individual and mixture toxicity predictions. It is widely recognized that ENMs trigger oxidative stress effects by generating intracellular reactive oxygen species (ROS), serving as a key mechanism in their cytotoxicity studies. However, existing in silico methods still face significant challenges in predicting the oxidative stress effects induced by ENMs.
View Article and Find Full Text PDFToxics
December 2024
Aquatic Contaminants Research Division, Environment and Climate Change Canada, 105 McGill, Montréal, QC H2Y 2E7, Canada.
Rare earth elements (REEs) are considered as emerging contaminants due to their use in the fabrication process of current technologies. As such, their aquatic toxicity, especially as a mixture, is not well understood, as it has been scarcely investigated. The purpose of this study was to shed light on the sublethal and lethal toxicity of a realistic mixture of five REE in .
View Article and Find Full Text PDFPharmaceuticals (Basel)
November 2024
Faculty of Physics, Sofia University "St. Kliment Ohridski", 5 James Bourchier Blvd, 1164 Sofia, Bulgaria.
Objectives: The antimicrobial, oxidative activities, and ecotoxicity of synthesized silver-loaded zeolites (X and ZSM-5(MFI), Si-to-Al ratios 12 and 25) were studied, linking antimicrobial properties to material structure and released active silver species.
Methods: The materials were characterized by SEM, EDX, TEM, and XRPD. All materials, with a silver content of 1-3%wt for the Ss and about 35%wt for the X-zeolites, were tested against and .
J Toxicol Environ Health B Crit Rev
January 2025
Department of Ecology and Conservation, Institute of Natural Sciences, Federal University of Lavras, Lavras, MG, Brazil.
Terrestrial and aquatic ecosystems face various chemicals that might induce acute and/or long-term harm. To assess these impacts, ecotoxicological bioassays are essential. However, bioassays using animals, particularly mammals, are costly, time-consuming, and raise ethical concerns.
View Article and Find Full Text PDFSci Data
January 2025
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
The global decline in bee populations poses significant risks to agriculture, biodiversity, and environmental stability. To bridge the gap in existing data, we introduce ApisTox, a comprehensive dataset focusing on the toxicity of pesticides to honey bees (Apis mellifera). This dataset combines and leverages data from existing sources such as ECOTOX and PPDB, providing an extensive, consistent, and curated collection that surpasses the previous datasets.
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