AI Article Synopsis
- - Dengue virus can cause a variety of symptoms, from no symptoms at all to severe illness, but the reasons for severe cases are still unclear.
- - Research has shown that in severe dengue cases, the complement system—part of the immune response—is overly activated, particularly involving a protein known as C1q.
- - C1q can attach to the dengue virus, and when combined with the virus before it infects certain immune cells, it reduces the virus's ability to infect and alters the expression of genes related to inflammation.
Article Abstract
Dengue virus infection elicits a spectrum of clinical presentations ranging from asymptomatic to severe disease. The mechanisms leading to severe dengue are not known, however it has been reported that the complement system is hyper-activated in severe dengue. Screening of complement proteins demonstrated that C1q, a pattern recognition molecule, can bind directly to dengue virus envelope protein and to whole dengue virus serotype 2. Incubation of dengue virus serotype 2 with C1q prior to infection of THP-1 cells led to decreased virus infectivity and modulation of mRNA expression of immunoregulatory molecules suggesting reduced inflammatory responses.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946857 | PMC |
| http://dx.doi.org/10.1016/j.virusres.2013.11.007 | DOI Listing |
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