Amide bond formation via C(sp3)-H bond functionalization and CO insertion.

Chem Commun (Camb)

Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.

Published: January 2014

An efficient method for the synthesis of amides via Pd-catalyzed oxidative carbonylation of C(sp(3))-H bonds with CO and amines is described. The route efficiently provides substituted phenyl amides from alkanes.

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Source
http://dx.doi.org/10.1039/c3cc47015fDOI Listing

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