Identification and molecular genetic analysis of the cichorine gene cluster in .

Medchemcomm

Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, California 90089, USA.

Published: August 2012

AI Article Synopsis

  • The phytotoxin cichorine is produced by a specific organism, which was recently demonstrated.
  • Researchers identified a cluster of seven essential genes that are necessary for the biosynthesis of cichorine through targeted deletions.
  • Two of the deletions resulted in molecules that provide insights into the biosynthetic pathway of this metabolite.

Article Abstract

We recently demonstrated that the phytotoxin cichorine is produced by . Through a set of targeted deletions, we have found a cluster of seven genes that are required for its biosynthesis. Two of the deletions yielded molecules that give information about the biosynthesis of this metabolite.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826659PMC
http://dx.doi.org/10.1039/C2MD20055DDOI Listing

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