Background: Adolescents have limited knowledge about medicines and their potential adverse effects. In this context, we aimed to investigate the basic knowledge of medicines, any differences in knowledge related to practice of self-medication (SM), attitudes towards SM and sources of information about medicines among expatriate adolescents in the United Arab Emirates (UAE).
Methods: A cross-sectional survey was conducted among 324 students from four schools in the UAE using a self-administered questionnaire. Data were analyzed using SPSS version 19.
Results: The sample of multi-ethnic students, with ages ranging from 14 to 19 years, was almost equally distributed between the genders. A total of 289 students reported to be self-medicating. More than 60% of adolescents had responded incorrectly to eight questions related to knowledge about medicines. There were no significant differences between mean scores for drug knowledge (maximum score=22) of self-medicating adolescents (12.1±4.32; SMAs) and those not practicing SM (12±4.53; NSMAs). Self-assessment of drug knowledge was perceived as good by 33% and satisfactory by 34% of SMAs. The majority of adolescents (87%) believed that SM was acceptable and reported being aware of its advantages and disadvantages. Parents and pharmacists were common sources of information about medicines.
Conclusion: The participants showed a positive inclination towards SM. The SMAs and NSMAs had similar knowledge about medicines. However, gaps in knowledge may lead to drug misuse and toxicity. Healthcare providers, pharmacists, educators and parents should be actively involved in health education strategies for rational use of medicines among adolescents in the UAE.
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http://dx.doi.org/10.1515/ijamh-2013-0315 | DOI Listing |
HGG Adv
January 2025
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Inherited genetics represents an important contributor to risk of esophageal adenocarcinoma (EAC), and its precursor Barrett's esophagus (BE). Genome-wide association studies have identified ∼30 susceptibility variants for BE/EAC, yet genetic interactions remain unexamined. To address challenges in large-scale G×G scans, we combined knowledge-guided filtering and machine learning approaches, focusing on genes with (A) known/plausible links to BE/EAC pathogenesis (n=493) or (B) prior evidence of biological interactions (n=4,196).
View Article and Find Full Text PDFEur J Hum Genet
January 2025
Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India.
Mitochondrial membrane protein-associated neurodegeneration (MPAN) is a rare neurodegenerative disorder characterized by spastic paraplegia, parkinsonism and psychiatric and/or behavioral symptoms caused by variants in gene encoding chromosome-19 open reading frame-12 (C19orf12). We present here seven patients from six unrelated families with detailed clinical, radiological, and genetic investigations. Childhood-onset patients predominantly had a spastic ataxic phenotype with optic atrophy, while adult-onset patients were presented with cognitive, behavioral, and parkinsonian symptoms.
View Article and Find Full Text PDFJ Assist Reprod Genet
January 2025
Meir Medical Center, Kfar Saba, Israel.
Purpose: Studies have shown mixed findings regarding the impact of stress on the success of fertility treatments. To the best of our knowledge, stress in the context of the workplace has not been investigated to date in relation to the success of fertility treatments. This research investigates the impact of work-related stress and emotional exhaustion experienced by both partners on in vitro fertilization (IVF) treatment outcomes.
View Article and Find Full Text PDFCardiooncology
January 2025
ProCardio Center for Innovation, Department of Cardiology, Oslo University Hospital, Oslo, Norway.
Background: Although anthracycline-related cardiotoxicity is widely studied, only a limited number of echocardiographic studies have assessed cardiac function in breast cancer survivors (BCSs) beyond ten years from anthracycline treatment, and the knowledge of long-term cardiorespiratory fitness (CRF) in this population is scarce. This study aimed to compare CRF assessed as peak oxygen uptake (V̇O), cardiac morphology and function, and cardiovascular (CV) risk factors between long-term BCSs treated with anthracyclines and controls with no history of cancer.
Methods: The CAUSE (Cardiovascular Survivors Exercise) trial included 140 BCSs recruited through the Cancer Registry of Norway, who were diagnosed with breast cancer stage II to III between 2008 and 2012 and had received treatment with epirubicin, and 69 similarly aged activity level-matched controls.
J Cardiothorac Surg
January 2025
Department of Traditional Chinese Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Background: Malignant esophageal mediastinal fistula is a severe complication that occurs in both the advanced stages of esophageal cancer and after radiotherapy for esophageal cancer. Esophageal mediastinal fistula is very susceptible to complications such as mediastinitis and mediastinal abscess, resulting in a significantly elevated mortality rate for patients. We reported a rare case of esophageal mediastinal fistula after immunotherapy for non-small cell lung cancer (NSCLC).
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