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Abnormal Astrocyte Heterogeneity in the Dentate Gyrus of Rats Prone to Audiogenic Seizures Can Be Corrected by the Nootropic Drug Piracetam.
Hippocampus
January 2025
Sechenov Institute of Evolutionary Physiology and Biochemistry, The Russian Academy of Sciences, Saint Petersburg, Russia.
Accumulating evidence indicates that inherited astrocyte dysfunction can be a primary trigger for epilepsy development; however, the available data are rather limited. In addition, astrocytes are considered as a perspective target for the design of novel and improvement of the existing antiepileptic therapy. Piracetam and related nootropic drugs are widely used in the therapy of various epileptic disorders, but detailed mechanisms of racetams action and, in particular, their effects on glial functions are poorly understood.
View Article and Find Full Text PDFGeneration and Characterization of Three Novel Mouse Mutant Strains Susceptible to Audiogenic Seizures.
Cells
October 2024
Institute of Cell Biophysics of the Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", 142290 Pushchino, Russia.
The mechanisms of epileptogenesis after brain injury, ischemic stroke, or brain tumors have been extensively studied. As a result, many effective antiseizure drugs have been developed. However, there are still many patients who are resistant to therapy.
View Article and Find Full Text PDFRepeated acoustic stimulation (audiogenic kindling) induces estrous arrest in the Wistar audiogenic Rat (WAR) strain. A model of pseudopregnancy?
Epilepsy Behav
December 2024
Department of Gynecology and Obstetrics, Ribeirão Preto Medical School, University of Sao Paulo (FMRP-USP), Ribeirão Preto, Brazil. Electronic address:
Article Synopsis
- Epilepsy, affecting over 50 million people globally, is characterized by seizures, and this study investigates its impact on the estrous cycle in female rats during acoustic stimulation.
- Wistar rats generally showed no significant changes in their estrous cycles or seizure episodes, while Wistar Audiogenic Rats (WAR) displayed irregular cycles, particularly under kindling conditions, leading to prolonged diestrus periods and increased seizure behaviors.
- The findings suggest that chronic audiogenic seizures in WAR females disrupt the normal estrous cycle, resulting in a pattern similar to pseudopregnancy, with diestrus arrests lasting around 10-12 days.
Aging of Krushinsky-Molodkina audiogenic rats is accompanied with pronounced neurodegeneration and dysfunction of the glutamatergic system in the hippocampus.
Brain Res
January 2025
Sechenov Institute of Evolutionary Physiology and Biochemistry, the Russian Academy of Sciences, St. Petersburg, Russian Federation. Electronic address:
Advancing age strongly correlates with an increased risk of epilepsy development. On the other hand, epilepsy may exacerbate the negative effects of aging making it pathological. In turn, the possible link between aging and epileptogenesis is dysregulation of glutamatergic transmission.
View Article and Find Full Text PDFAssessing the Effectiveness of Eslicarbazepine Acetate in Reducing Audiogenic Reflex Seizures in the GASH/Sal Model of Epilepsy.
Biomedicines
May 2024
Institute for Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain.
Eslicarbazepine acetate (ESL) is a third-generation antiepileptic drug indicated as monotherapy for adults with newly diagnosed epilepsy and as adjunctive therapy for the treatment of partial seizures. Our aim was to assess the effectiveness and safety of both acute and repeated ESL administration against reflex audiogenic seizures, as shown by the Genetic Audiogenic Seizures Hamster from Salamanca (GASH/Sal). Animals were subject to the intraperitoneal administration of ESL, applying doses of 100, 150 and 200 mg/kg for the acute study, whereas a daily dose of 100 mg/kg was selected for the subchronic study, which lasted 14 days.
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