In this study, we investigated the toxic effects of nanocarbon blacks (NCBs) with different sizes to mouse macrophage RAW264.7 cells. MTT and fluorescence-based LIVE assays demonstrated that NCBs uptake caused a size and dose-dependent growth inhibition to the cells. Optical microscopy observations and (99m)Tc radionuclide labeling techniques were used to investigate the cellular uptake of NCBs with different sizes qualitatively and quantitatively, respectively. Results showed that the cellular uptake amounts of NCBs increased with their increasing size. Large quantities of internal NCBs induced oxidative stress and nuclear damage in cells; these effects may be the critical factors involved in the cytotoxicity of NCBs. The implications associated with these findings are discussed.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856077 | PMC |
| http://dx.doi.org/10.3390/ijms141122529 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Revealing Kinetic Features of a Macrocyclization Reaction using Machine-Learning-Augmented Data.
Angew Chem Int Ed Engl
March 2025
Tokyo Daigaku, Dept Chem, JAPAN.
We developed a method to reveal the kinetic features of macrocyclization using machine-learning-augmented data. Thirty-six experimental yield datasets were expanded to two hundred datasets through machine learning, enabling kinetic analyses of concentration-dependent yields. This augmented data allowed the chemistry underlying the predictive black box to be elucidated, providing quantitative insights such as rate constants and effective molarity through least-squares fitting of differential rate equations.
View Article and Find Full Text PDFA Multi-Phase Analytical Model for Effective Electrical Conductivity of Polymer Matrix Composites Containing Micro-SiC Whiskers and Nano-Carbon Black Hybrids.
Polymers (Basel)
January 2025
Advanced Manufacturing Institute, King Saud University, P.O. Box 800, Riyadh 11421, Saudi Arabia.
Multifunctional polymer composites containing micro/nano hybrid reinforcements have attracted intensive attention in the field of materials science and engineering. This paper develops a multi-phase analytical model for investigating the effective electrical conductivity of micro-silicon carbide (SiC) whisker/nano-carbon black (CB) polymer composites. First, CB nanoparticles are dispersed within the non-conducting epoxy to achieve a conductive CB-filled nanocomposite and its electrical conductivity is predicted.
View Article and Find Full Text PDFBright, circularly polarized black-body radiation from twisted nanocarbon filaments.
Science
December 2024
Center for Complex Particle Systems (COMPASS), University of Michigan, Ann Arbor, MI, USA.
Planck's law ignores but does not prohibit black-body radiation (BBR) from being circularly polarized. BBR from nanostructured filaments with twisted geometry from nanocarbon or metal has strong ellipticity from 500 to 3000 nanometers. The submicrometer-scale chirality of these filaments satisfies the dimensionality requirements imposed by fluctuation-dissipation theorem and requires symmetry breaking in absorptivity and emissivity according to Kirchhoff's law.
View Article and Find Full Text PDFHeating and Strain Sensing Elements Based on Segregated Polyethylene/Carbon Black Composites in Polymer Welded Joints.
Materials (Basel)
August 2024
Center of Polymer and Carbon Materials, Polish Academy of Sciences, 34. M. Curie-Skłodowskiej St., 41-800 Zabrze, Poland.
The development of easy and direct real-time monitoring of welded joint quality instead of surface damage analysis is crucial to improve the quality of industrial products. This work presents the results of high-density polyethylene (HDPE)-based composites with various carbon black (CB) content (from 20 to 30 vol.%) for use as a heating element and strain sensor in electrofusion-welded polymer joints.
View Article and Find Full Text PDFFabrication and Characterization of PLA/PBAT Blends, Blend-Based Nanocomposites, and Their Supercritical Carbon Dioxide-Induced Foams.
Polymers (Basel)
July 2024
Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan 333, Taiwan.
In this study, a twin-screw extruder was used to fabricate poly(lactic acid) (PLA)/poly(butylene adipate-co-terephthalate) (PBAT) blends and blend-based nanocomposites with carbon nanotube (CNT) or nanocarbon black (CB) as nanofillers. The fabricated samples were subsequently treated with supercritical carbon dioxide (scCO) to fabricate the corresponding foams. Bi-phasic morphology and selective distribution of CNTs or CBs in the PBAT phase were observed in the blends/composites through scanning electron microscopy.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!