AI Article Synopsis
- Rhabdomyosarcoma (RMS) is the most prevalent soft tissue sarcoma in children, while undifferentiated pleomorphic sarcoma (UPS) is common in adults.
- Researchers used genetically modified mice (Pax7-CreER and MyoD-CreER) to study the origin of these cancers by manipulating key genes involved in muscle development.
- Results showed that RMS and UPS have unique yet overlapping origins in muscle cells, highlighting their distinct biological characteristics and aiding in the creation of mouse models for further investigation of these sarcomas.
Article Abstract
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, whereas undifferentiated pleomorphic sarcoma (UPS) is one of the most common soft tissue sarcomas diagnosed in adults. To investigate the myogenic cell(s) of origin of these sarcomas, we used Pax7-CreER and MyoD-CreER mice to transform Pax7(+) and MyoD(+) myogenic progenitors by expressing oncogenic Kras(G12D) and deleting Trp53 in vivo. Pax7-CreER mice developed RMS and UPS, whereas MyoD-CreER mice developed UPS. Using gene set enrichment analysis, RMS and UPS each clustered specifically within their human counterparts. These results suggest that RMS and UPS have distinct and overlapping cells of origin within the muscle lineage. Taking them together, we have established mouse models of soft tissue sarcoma from muscle stem and progenitor cells.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893104 | PMC |
| http://dx.doi.org/10.1016/j.celrep.2013.10.020 | DOI Listing |
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