AI Article Synopsis
- The review explores how clinical features relate to the prognosis of patients experiencing limb-shaking TIA (LS-TIA), emphasizing the significance of accurate diagnosis in treatment outcomes.
- A total of 63 LS-TIA cases, primarily linked to atherosclerotic issues, were analyzed, revealing that many patients were initially misdiagnosed as having epilepsy, leading to ineffective treatment.
- Results indicate that revascularization therapy significantly improves patient prognosis over conventional drug treatments, highlighting the need for better approaches to managing LS-TIA and preventing ischemic strokes.
Article Abstract
Objective: This review aims to illustrate the relationship between clinical features and the prognosis of patients with limb-shaking transient ischemic attack (LS-TIA).
Data Sources: Relevant articles published in two main Chinese medical periodical databases (China National Knowledge Infrastructure and China Science Periodical Database) from 1986 to June 2013 were identified with keywords "limb shaking" and "transient ischemic attack".
Study Selection: Original articles and case reports about LS-TIA were selected.
Results: A total of 63 cases collected from 19 articles were included in the pooled analysis. LS-TIA presented in two cerebrovascular diseases, of which atherosclerotic high-grade stenosis or occlusion in carotid artery system and moyamoya disease formed 95.2% and 4.8%, respectively. Of 63 patients, 11 (17.5%) were once misdiagnosed as epileptic and prescribed useless antiepilepsy drugs. The multivariable Logistic regression model showed a significant protective effect of patients with revascularization therapy on prognosis, compared with patients treated with drugs (odds ratio 0.20, 95% CI 0.05-0.74, P = 0.016).
Conclusions: Chronic carotid artery system hypoperfusion can induce limb(s) shaking, followed by high possibility of ischemic stroke in the same brain territorial. Revascularization of the responsible artery may work better than conservative drug-based therapy.
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