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GWAS analysis revealed genomic loci and candidate genes associated with the 100-seed weight in high-latitude-adapted soybean germplasm.
Theor Appl Genet
January 2025
Research Center for Life Sciences Computing, Zhejiang Lab, Hangzhou, 310012, China.
In the present study, we identified 22 significant SNPs, eight stable QTLs and 17 potential candidate genes associated with 100-seed weight in soybean. Soybean is an economically important crop that is rich in seed oil and protein. The 100-seed weight (HSW) is a crucial yield contributing trait.
View Article and Find Full Text PDFThe Association of HLA-E Ligand and NKG2 Receptor Variation with Relapse and Mortality after Haploidentical Related Donor Transplantation.
Transplant Cell Ther
January 2025
Division of Clinical Research, Fred Hutchinson Cancer Center, Seattle, WA.
Background: Recurrence of blood malignancy is the major cause of mortality after hematopoietic cell transplantation. NKG2 receptor/HLA-E ligand complexes play a fundamental role in the surveillance and elimination of transformed cells but their role in the control of leukemia in transplantation is unknown.
Objective: We tested the hypothesis that gene variation of patient and/or donor HLA-E ligand and donor NKG2C-NKG2A receptors are associated with the risks of relapse and mortality (primary endpoints) and GVHD and non-relapse mortality (secondary endpoints) after haploidentical transplantation.
Utilization of natural alleles and haplotypes of Ctb1 for rice cold adaptability.
Gene
January 2025
College of Agriculture, Hunan Agricultural University, Changsha, Hunan 410128, China. Electronic address:
Article Synopsis
- Cold stress during the booting stage of rice severely impacts yields, especially in colder regions, prompting a study on the Ctb1 gene for developing cold-tolerant rice varieties.
- Researchers identified key genetic variations (InDels and SNPs) in the Ctb1 promoter, with a specific InDel at -1,302 bp significantly enhancing Ctb1 expression and cold tolerance.
- The introduction of this beneficial InDel into a cold-sensitive rice variety led to substantial improvements in cold survival, seed setting rates, and overall yield, highlighting its importance for breeding resilient rice.
Intraspecific variation and functional study of VERL polymorphism in Pacific abalone (Haliotis discus hannai Ino) and giant abalone (H. gigantea Gmelin).
Int J Biol Macromol
January 2025
State Key Laboratory of Mariculture Breeding, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, China; Fujian Key Laboratory of Genetics and Breeding of Marine Organisms, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, China. Electronic address:
Article Synopsis
- Sperm and eggs have specific proteins called gamete recognition proteins (GRPs) that influence their compatibility in fertilization, and this study focuses on the VERL receptor in two abalone species.
- The full-length VERL sequences were found to be different in Pacific abalone (11,373 bp) and giant abalone (9,405 bp), with variations in their amino acid compositions and repeats.
- Notably, the study discovered a relationship between VERL genotypes and mating preferences in giant abalone, highlighting amino acid diversity's role in fertilization and providing insights for improving abalone breeding practices.
Association of MTHFR C677T and A1298C variants with preeclampsia risk and angiogenic imbalance in Tunisian women.
Pregnancy Hypertens
January 2025
Faculté des Sciences de Tunis, Université de Tunis El Manar, Tunis, Tunisia; Department of Biological Sciences, Brock University, St. Catharines, Canada. Electronic address:
Unlabelled: Preeclampsia (PE) is a pregnancy-specific vascular disorder associated with endothelial dysfunction, hypertension, and proteinuria. The methylenetetrahydrofolate reductase (MTHFR) enzyme regulates essential cellular functions in pregnancy owing to its effects on folate metabolism and DNA methylation. Previous studies implicated the association of rs1801133 (C677T; Ala222Val) and rs1801131 (A1298C; Glu429Ala) in the MTHFR gene with PE in different ethnic groups, but with mixed outcomes.
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