AI Article Synopsis
- Vitiligo is a skin disorder characterized by the loss of pigment, and some reports suggest that proton pump inhibitors (PPIs) may worsen this condition.
- Research was conducted to evaluate the impact of PPIs on melanin production in both lab-grown cells and living zebrafish.
- The study found that PPIs decreased melanin levels and activity of the enzyme involved in pigmentation, indicating that their use could potentially worsen vitiligo in susceptible individuals.
Article Abstract
Background: Vitiligo is an acquired depigmentation disorder of melanocytes. Recently, some clinical reports have suggested that proton pump inhibitors (PPIs) may worsen vitiligo, but their effects on melanocytes have yet to be elucidated.
Objective: We investigated the effect of PPIs on melanogenesis in vivo and in vitro.
Methods: We examined the effect of PPIs on melanogenesis in B16 murine melanoma cells by measuring melanin content and tyrosinase (TYR) activity. TYR and tyrosinase-related protein-1 (TRP-1) were monitored by western blotting. Finally, a PPI was applied to zebrafish embryos to investigate its in vivo effect on pigmentation.
Results: In agreement with our clinical experience of worsened vitiligo after PPI treatment, PPIs decreased both melanin content and TYR activity. Western blotting showed that PPIs decreased TYR and TRP-1 protein levels. In the zebrafish test, PPIs inhibited body pigmentation in a dose-dependent manner.
Conclusion: These results suggest that the functional inhibition of melanization by PPIs may induce or aggravate vitiligo lesions in genetically predisposed patients.
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| http://dx.doi.org/10.1111/jdv.12317 | DOI Listing |
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