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High-Throughput Effect-Directed Analysis of Androgenic Compounds in Hospital Wastewater: Identifying Effect Drivers through Non-Target Screening Supported by Toxicity Prediction.
Environ Sci Technol
January 2025
Department Exposure Science, Helmholtz Centre for Environmental Research─UFZ, 04318 Leipzig, Germany.
The increasing number of contaminants released into the environment necessitates innovative strategies for their detection and identification, particularly in complex environmental matrices like hospital wastewater. Hospital effluents contain both natural and synthetic hormones that might significantly contribute to endocrine disruption in aquatic ecosystems. In this study, HT-EDA has been implemented to identify the main effect-drivers (testosterone, androsterone and norgestrel) from hospital effluent using microplate fractionation, the AR-CALUX bioassay and an efficient data processing workflow.
View Article and Find Full Text PDFFish models to explore epigenetic determinants of hypoxia-tolerance.
Comp Biochem Physiol A Mol Integr Physiol
January 2025
Department of Biology, University of Ottawa, K1N6N5, 20 Marie Curie, Ottawa, ON, Canada. Electronic address:
The occurrence of environmental hypoxia in freshwater and marine aquatic systems has increased over the last century and is predicted to further increase with climate change. As members of the largest extant vertebrate group, freshwater fishes, and to a much lesser extent marine fishes, are vulnerable to increased occurrence of hypoxia. This is important as fishes render important ecosystem services and have important cultural and economic roles.
View Article and Find Full Text PDFLethal and sublethal effects of flupyradifurone and cyantraniliprole on two neotropical stingless bee species.
Ecotoxicology
January 2025
Tecnológico Nacional de México, Instituto Tecnológico de Conkal, Conkal, Yucatán, Mexico.
Stingless bees are important pollinators in tropical regions, but their survival and behavior have been impacted by various factors, including exposure to insecticides. Here, we evaluated the lethal and sublethal effects of commercial formulations of two widely used insecticides, flupyradifurone (FPF formulation), and cyantraniliprole (CY formulation), on Melipona beecheii and Nannotrigona perilampoides. The study involved oral exposure of bees to insecticides, calculation of the lethal concentration (LC) and the lethal time (LT), and evaluation of walking and flight take-off activities.
View Article and Find Full Text PDFEnzymatic activity and gene expression changes in the earthworms induced by co-exposure to beta-cypermethrin and triadimefon.
Ecotoxicology
January 2025
Anshun City Branch of Guizhou Tobacco Company, Anshun, Guizhou, China.
Pesticides often exist as complex mixtures in soil environments, yet the toxicity of these combinations has not been thoroughly investigated. In light of this, the current study aimed to assess the enzymatic activity and gene expression responses in the earthworm Eisenia fetida when exposed to a mixture of beta-cypermethrin (BCY) and triadimefon (TRI). The findings revealed that co-exposure to BCY and TRI triggered acute synergistic toxicity in E.
View Article and Find Full Text PDFToxic Effects of Lead Exposure on Freshwater Climbing Perch, , and Bioremediation Using Leaf Powder.
Toxics
December 2024
Ecotoxicology Research Laboratory, Department of Zoology, The University of Burdwan, Burdwan 713104, West Bengal, India.
The acute and chronic toxicity of lead to was determined in this study using static replacement bioassay testing. During the chronic toxicity studies, an experiment on the bioremediation of lead toxicity using leaf powder was conducted. The 96 h LC values of lead for was 1.
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