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| http://dx.doi.org/10.1136/bcr-2013-200478 | DOI Listing |
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Clinical Manifestations.
Alzheimers Dement
December 2024
Massachusetts General Hospital, Boston, MA, USA.
Background: PET quantifies tau and amyloid-ß (Aß) pathology in preclinical AD. A 2-min digital clock-drawing test (DCTclock ) captures clock-drawing outcomes and processes, potentially more sensitive to cognitive deficits in preclinical AD than pencil-and-paper tests. The DCTclock summary score comprised subscores targeting multi-domain cognitive performance (i.
View Article and Find Full Text PDFA cross-tissue transcriptome-wide association study identifies new susceptibility genes for insomnia.
J Neurophysiol
January 2025
Department of Anesthesiology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Article Synopsis
- Insomnia has a genetic component (22-25% heritability), but key genetic regions influencing its risk are not well understood.
- Researchers utilized advanced methods like UTMOST and TWAS, combined with data from a large GWAS of over 462,000 Europeans and gene expression data, to study insomnia-related genes.
- The study identified two new susceptibility genes (VRK2 and MMRN1) linked to insomnia, found specific brain regions enriched with related SNPs, and highlighted important biological pathways that could lead to future treatment options.
Sports participation & childhood neurocognitive development.
Dev Cogn Neurosci
December 2024
Physical Education and Sports Science Department, National Institute of Education, Nanyang Technological University, Singapore. Electronic address:
Various psychosocial factors like collaboration inherent to team sports might provide a more dynamic environment for cognitive challenges that could foster enhanced neurocognitive development compared to individual sports. We investigated the impact of different organised sports on neurocognitive development in children (N = 11,878; aged 9-11) from the Adolescent Brain Cognitive Development (ABCD) study. Participants were classified into four categories based on their sports involvement at baseline and two years later: none, individual-based, team-based, or both.
View Article and Find Full Text PDFEarly radiological reduction of periventricular anastomosis after direct bypass surgery for adult moyamoya disease.
J Neurosurg
December 2024
Departments of1Neurosurgery.
Objective: Periventricular anastomosis (PA), a recently recognized cause of hemorrhage in moyamoya disease, is reducible after bypass surgery. The timing of the reduction, however, remains poorly understood. The objectives of the present study were to demonstrate radiological reduction of PA occurring within 48 hours after surgery and to identify factors associated with reduction.
View Article and Find Full Text PDFSubtypes of cognitive impairment in cerebellar disease identified by cross-diagnostic cluster-analysis: results from a German multicenter study.
J Neurol
December 2024
Department of Neurology, Essen University Hospital, University of Duisburg-Essen, Hufelandstraße 55, 45147, Essen, Germany.
Background: Cognitive and neuropsychiatric impairment, known as cerebellar cognitive affective syndrome (CCAS), may be present in cerebellar disorders. This study identified distinct CCAS subtypes in cerebellar patients using cluster analysis.
Methods: The German CCAS-Scale (G-CCAS-S), a brief screening test for CCAS, was assessed in 205 cerebellar patients and 200 healthy controls.
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