AI Article Synopsis
- - This text describes a new method for synthesizing acrylamidines using a strategy that involves the migration of a 1,3-amino group.
- - The process uses copper (Cu(i)) to catalyze the reaction between N,N-disubstituted propargylamine and tosylazide, resulting in a reactive ketenimine intermediate.
- - This reactive intermediate is then captured by a nearby amino group, resulting in a rearrangement reaction that facilitates the formation of the desired compound.
Article Abstract
A novel 1,3-amino group migration strategy for the synthesis of acrylamidines is presented. Cu(i) catalyzed reaction of N,N-disubstituted propargylamine with tosylazide generates a highly reactive ketenimine intermediate which is trapped by a tethered amino group leading to the rearrangement reaction.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/c3cc47182a | DOI Listing |
Publication Analysis
Top Keywords
13-amino group
8
group migration
8
migration route
4
route form
4
form acrylamidines
4
acrylamidines novel
4
novel 13-amino
4
migration strategy
4
strategy synthesis
4
synthesis acrylamidines
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!