AI Article Synopsis
- A 14-year-old male patient with hemophilia B is scheduled for posterior spinal fusion surgery for scoliosis, with a preoperative factor IX activity of 8.4% and no inhibitors present.
- *A specific dosage schedule for recombinant coagulation factor IX was created to sustain factor IX levels at or below 80% for the first 6 days and at or above 40% for the following week post-surgery.
- *The patient had a successful surgery with stable coagulation levels and did not require any blood transfusions, indicating effective management of his hemophilia during the procedure.
Article Abstract
Posterior spinal fusion for scoliosis was planned in a 14-year-old male patient with hemophilia B. Preoperative examination showed factor IX activity of 8.4% with no inhibitor development. A perioperative dosage schedule was prepared after examining the pharmacokinetics of recombinant coagulation factor IX in order to maintain levels of perioperative factor IX activity at < or = 80% for the first 6 days (days 0-6), and > or = 40% for days 7-14 postoperatively. The dose of recombinant coagulation factor IX was adjusted to maintain factor IX activity above 80%, while measuring coagulation activity every hour during the surgery. The patient showed a favorable course without hemorrhagic tendency. We could safely manage anesthesia without requiring allogeneic blood transfusion.
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