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Associations between interpersonal and community-level violence experiences and HIV outcomes: implications for violence screening in Ryan White Clinics.
AIDS Care
January 2025
Department of Behavioral, Social, and Health Education Sciences, Emory University Rollins School of Public Health, Atlanta, GA, USA.
Violence experience, interpersonal and community-level, is commonly reported by people living with HIV (PLWH). Understanding the impact of the various forms of violence on HIV outcomes is critical for prioritizing violence screening and support resources in care settings. From February 2021 to December 2022, among 285 PLWH purposively sampled to attain diversity by gender, race/ethnicity, and HIV care retention status in Atlanta, Georgia, we examined interpersonal and community violence experiences and proxy measures of violence (post-traumatic stress disorder (PTSD), anxiety, depression) and their associations with HIV outcomes (engagement and retention in care and HIV viral suppression) using multivariable analysis.
View Article and Find Full Text PDFADSL promotes autophagy and tumor growth through fumarate-mediated Beclin1 dimethylation.
Nat Chem Biol
January 2025
Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.
As an enzyme with a critical role in de novo purine synthesis, adenylosuccinate lyase (ADSL) expression is upregulated in various malignancies. However, whether ADSL possesses noncanonical functions that contribute to cancer progression remains poorly understood. Here, we demonstrate that protein kinase R-like endoplasmic reticulum kinase (PERK) activated by lipid deprivation or ER stress phosphorylates ADSL at S140, leading to an enhanced association between ADSL and Beclin1.
View Article and Find Full Text PDFBioengineering Approaches for Male Infertility: From Microenvironmental Regeneration to in vitro Fertilization.
Adv Exp Med Biol
January 2025
METU MEMS Center, Ankara, Turkey.
Male factor accounts for 30-50% of infertility cases and may occur due to congenital anomalies or acquired disorders. In such infertility cases where a limited number of mature sperm is produced, a solution is offered to patients with ART applications; however, these methods are inadequate in patients with germ cell aplasia due to damaged microenvironment. Since monolayer cell culture and static culture conditions do not provide the physical conditions of the 3D microenvironment, they have a limited effect on ensuring the execution of in vitro spermatogenesis properly.
View Article and Find Full Text PDFQuality of Life in Tourette Syndrome.
Psychiatr Clin North Am
March 2025
Department of Neuropsychiatry, BSMHFT and University of Birmingham, Birmingham, UK; Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology and University College London, London, UK; School of Life and Health Sciences, Aston Brain Centre, Aston University, Birmingham, UK; School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy. Electronic address:
Research conducted since the turn of the millennium has shown that the quality of life in patients with Tourette syndrome is affected by various health-related factors. The condition's chronic nature, along with its social and emotional implications, can significantly diminish the overall quality of life. Both core symptoms-motor and vocal tics-and associated comorbidities can contribute to functional impairments and reduced well-being.
View Article and Find Full Text PDFUnderstanding Health-Related Discussions on Reddit: Development of a Topic Assignment Method and Exploratory Analysis.
JMIR Form Res
January 2025
Larner College of Medicine, University of Vermont, Burlington, VT, United States.
Background: Social media has become a widely used way for people to share opinions about health care and medical topics. Social media data can be leveraged to understand patient concerns and provide insight into why patients may turn to the internet instead of the health care system for health advice.
Objective: This study aimed to develop a method to investigate Reddit posts discussing health-related conditions.
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