AI Article Synopsis
- Developed simple and economical methods for measuring pridinol mesylate in raw materials, including a volumetric and an HPLC approach.
- The volumetric method uses a reaction with sodium lauryl sulfate in diluted sulfuric acid and employs dimethyl yellow as an indicator.
- The HPLC method utilizes a reverse phase C18 column with a specific mobile phase and UV detection at 258 nm, achieving quantification based on peak area.
- Both methods are effective for quality control of pridinol mesylate.
Article Abstract
Simple, sensitive, and economical simultaneous volumetric and HPLC methods for the determination of pridinol mesylate in raw material have been developed. The volumetric method is based on the reaction of pridinol with sodium lauryl sulphate in diluted sulphuric acid. Dimethyl yellow was used as indicator to detect the end point of the titration in aqueous/organic layer. The HPLC method for the determination of pridinol mesylate employs a reverse phase C18 column at ambient temperature with a mobile phase consisting of acetonitrile: 0.05 M potassium dihydrogen phosphate, pH adjusted to 5.0 (1 : 2, v/v). The flow rate was 0.8 mL/min. Quantitation was achieved with UV detection at 258 nm based on peak area. Both methods were found to be suitable for the quality control of pridinol mesylate in raw material.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809392 | PMC |
| http://dx.doi.org/10.1155/2013/540676 | DOI Listing |
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