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Detection of cytomegalovirus DNA in colorectal tissue from Swedish and Vietnamese patients with colorectal cancer. | LitMetric

AI Article Synopsis

  • - The study investigated the presence of Human cytomegalovirus (HCMV) DNA in colorectal cancer (CRC) tissues versus normal tissues, suggesting that HCMV may influence CRC progression.
  • - Results showed that HCMV DNA was found more frequently in cancerous tissues (39.8% in Vietnamese patients vs. 15.1% in Swedish patients), and there was a higher prevalence in those with advanced disease.
  • - The data indicates a significant difference in HCMV DNA prevalence between cancerous and normal tissues, and highlights ethnic variations in prevalence between the Swedish and Vietnamese populations.

Article Abstract

Background: Human cytomegalovirus (HCMV) has been implicated as a factor, which might be associated with colorectal cancer (CRC) progression. Data from studies with HCMV-infected tumour cell lines have highlighted an oncomodulatory potential of HCMV. In the present study, we aimed to evaluate the prevalence of HCMV DNA in CRC tissue compared to matched normal tissue, and its association with clinical factors.

Patients And Methods: We used quantitative real-time polymerase chain reaction assay to detect HCMV DNA in 202 cancerous and paired normal tissue from Swedish (n=119) and Vietnamese (n=83) CRC patients.

Results: Overall, the HCMV DNA rate was significantly higher in cancerous in relation to paired normal tissue. Furthermore, a significantly higher frequency (39.8%) of HCMV DNA was observed in cancer tissues from the Vietnamese patients compared to the Swedish patients (15.1%). The prevalence of HCMV DNA in CRC tissue of 50% of those with disseminated disease tended to be higher compared to those with localized disease, with a prevalence of 33.3% in Vietnamese patients.

Conclusion: Our observations indicate that the prevalence of HCMV DNA differs significantly between cancer and matched normal tissues. Thus, these data support a possible role of CMV in CRC. Moreover, we noted differences between Swedish and Vietnamese patients, indicating a role of ethnicity.

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