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Efficacy & safety of brolucizumab 6.0 mg versus 3.6 mg in diabetic macular edema.
Int J Retina Vitreous
January 2025
Army Hospital Research & Referral, Delhi Cantt, New Delhi, Delhi, 110010, India.
Background: Management of Diabetic Macular edema (DME) requires repeated injections. Therefore newer Anti-VEGFs like Brolucizumab with longer durability have been introduced. We compared two different dosages of Brolucizumab, 6.
View Article and Find Full Text PDFUncomplicated Amyand's hernia in a setting of abdominal wall insufficiency: a case report.
J Med Case Rep
January 2025
Dept. of General Surgery, Fortis Hospital, Sector 62, Noida, UP, 201309, India.
Introduction: Amyand's hernia, an uncommon condition characterized by the presence of the appendix within an inguinal hernial sac (< 1% incidence), poses diagnostic and therapeutic challenges. Often it is an intraoperative finding, with almost no clinical symptoms.
Case Presentation: This is a case of an Indian male in his early 80 years, diagnosed with bilateral direct inguinal hernias, one of which contained a noninflamed appendix.
Boswellic acid synergizes with low-dose ionizing radiation to mitigate thioacetamide-induced hepatic encephalopathy in rats.
BMC Pharmacol Toxicol
January 2025
Biochemistry Department, Faculty of Science, Ain-Shams University, Cairo, Egypt.
Hepatic encephalopathy (HE) is a syndrome that arises from acute or chronic liver failure. This study was devised to assess the impact of a combination of boswellic acid (BA) and low doses of gamma radiation (LDR) on thioacetamide (TAA)-induced HE in an animal model. The effect of daily BA treatment (175 mg/kg body weight, for four weeks) and/or fractionated low-dose γ-radiation (LDR; 0.
View Article and Find Full Text PDFStrengthening research preparedness for crises: lessons from Norwegian government agencies in using randomized trials and quasi-experimental methods to evaluate public policy interventions.
Health Res Policy Syst
January 2025
Centre for Epidemic Interventions Research, Norwegian Institute of Public Health, Oslo, Norway.
During public health crises such as pandemics, governments must rapidly adopt and implement wide-reaching policies and programs ("public policy interventions"). A key takeaway from the coronavirus disease 2019 (COVID-19) pandemic was that although numerous randomized controlled trials (RCTs) focussed on drugs and vaccines, few policy experiments were conducted to evaluate effects of public policy interventions across various sectors on viral transmission and other consequences. Moreover, many quasi-experimental studies were of spurious quality, thus proving unhelpful for informing public policy.
View Article and Find Full Text PDFManaging malice in negative environments: the mediating effect of coping styles on the relationship between negative sense of place and malevolent creativity among Chinese high school students.
BMC Psychol
January 2025
College of Education, Zhejiang Normal University, Yingbin Avenue, Jinhua, China.
Background: Creativity motivated by negative intentions can be referred to as malevolent creativity. While existing findings have largely focused on environmental or individual factors influencing malevolent creativity, less attention has been directed towards understanding how the sense of place-derived from individual-environment interaction-affects malevolent creativity. Additionally, the role of coping styles as mediating mechanisms in negative environments has been insufficiently explored.
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