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Analysis of the spiking dynamics of a diode laser with dual optical feedback.
Sci Rep
January 2025
Physics Department, Whitman College, Walla Walla, WA, 99362, USA.
In a complex dynamical system, noise, feedback, and external forces shape behavior that can range from regularity to high-dimensional chaos. Multiple feedback sources can significantly alter its dynamics, potentially even suppressing the system's output. This study investigates the impact of competing feedback sources on a stochastic complex dynamical system using a photonic neuron-a diode laser with external optical feedback.
View Article and Find Full Text PDFDifferential encoding of mammalian proprioception by voltage-gated sodium channels.
Sci Adv
January 2025
Department of Physiology and Membrane Biology, University of California, Davis, Davis, CA, USA.
Animals requiring purposeful movement for survival are endowed with mechanoreceptors, called proprioceptors, that provide essential sensory feedback from muscles and joints to spinal cord circuits, which modulates motor output. Despite the essential nature of proprioceptive signaling in daily life, the mechanisms governing proprioceptor activity are poorly understood. Here, we identified nonredundant roles for two voltage-gated sodium channels (Nas), Na1.
View Article and Find Full Text PDFGnRH pulse generator activity in mouse models of polycystic ovary syndrome.
Elife
January 2025
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Article Synopsis
- One in ten women of reproductive age have PCOS, characterized by subfertility, high LH levels, and potential dysfunction in the kisspeptin neurons that regulate GnRH.
- Researchers studied the GnRH pulse generator in two mouse models of PCOS: the peripubertal androgen (PPA) model showed fewer synchronized neuron events, while the prenatal androgen (PNA) model revealed variable GnRH activity but cyclical patterns indicating complexity.
- Findings indicate that in the PNA model, ARN neurons had increased activity during specific stages and less sensitivity to progesterone, highlighting the need to understand GnRH regulation in PCOS-related conditions.
Elevated p16Ink4a Expression Enhances Tau Phosphorylation in Neurons Differentiated From Human-Induced Pluripotent Stem Cells.
Aging Cell
January 2025
Department of Pediatrics, 3 NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Increased expression of the cyclin-dependent kinase inhibitor p16Ink4a (p16) is detected in neurons of human Alzheimer's disease (AD) brains and during normal aging. Importantly, selective eliminating p16-expressing cells in AD mouse models attenuates tau pathologies and improves cognition. But whether and how p16 contributes to AD pathogenesis remains unclear.
View Article and Find Full Text PDFEfficacy of brain-computer interface training with motor imagery-contingent feedback in improving upper limb function and neuroplasticity among persons with chronic stroke: a double-blinded, parallel-group, randomized controlled trial.
J Neuroeng Rehabil
January 2025
Translational Research Center for Rehabilitation Robots, National Rehabilitation Center, Ministry of Health and Welfare, Seoul, Korea.
Background: Brain-computer interface (BCI) technology can enhance neural plasticity and motor recovery in persons with stroke. However, the effects of BCI training with motor imagery (MI)-contingent feedback versus MI-independent feedback remain unclear. This study aimed to investigate whether the contingent connection between MI-induced brain activity and feedback influences functional and neural plasticity outcomes.
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