AI Article Synopsis
- The study aimed to investigate how the ethanol extract of yellowish Meliae Toosendan Fructus affects the nervous system and its underlying mechanisms.
- Using various pain models and electrical stimulation on mice, researchers measured changes in sensory and motor nerve function, including pain thresholds and conduction velocity.
- Results indicated that the extract increased pain thresholds while decreasing motor nerve conduction velocity, possibly due to a reduction in Schwann cells and demyelination in the motor nerves.
Article Abstract
Objective: To study the effect of the ethanol extract of stir-bake to yellowish Meliae Toosendan Fructus on nerve system and its mechanism.
Methods: The effect of the ethanol extract on sensory nerve was carried out through ache models induced by hot board method and radiant heat stimulation method in mice. The thermalgesia liminal value was investigated. The effect of the ethanol extract on the A-delta fiber and C fiber was measured by electrical stimulation procedure. Motor nerve conduction velocity (NCV) was measured by indirect detection method in vivo. The pathology changes of the motor nerve were observed by transmission electron microscope and the silver stain test.
Results: The ethanol extract of Meliae Toosendan Fructus could increase the thermalgesia liminal value of mice and reduce the conduction velocity of motor nerves. Meanwhile, pathology results showed the changes of the fiber of motor nerve, including demyelination and the number of Schwann cells dropping.
Conclusion: The ethanol extract of stir-bake to yellowish Meliae Toosendan Fructus can reduce the pain sensitivity of mice and slow down NCV, which may be related to decreasing of the number of Schwann cells.
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