Pyrosequencing represents one of the most thorough methods used to analyze polymorphisms. One advantage of using pyrosequencing for genotyping is the ability to identify not only single-nucleotide polymorphisms (SNPs) but also tri-allelic variations, insertions and deletions (InDels). In contrast to most other genotyping assays the sequence surrounding the polymorphism provides an internal control making this method highly reliable.
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Emergency Department, Foshan Women and Children Hospital, Foshan528200, China.
Article Synopsis
- The study aimed to understand how a specific genetic variation (SNP) in the FCN gene influences the risk of pre-eclampsia (PE) in pregnant Han nationality women, comparing 274 women with PE to 154 healthy controls.
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