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Therapeutic effects of suppressors of cytokine signaling in diabetic nephropathy. | LitMetric

Therapeutic effects of suppressors of cytokine signaling in diabetic nephropathy.

J Histochem Cytochem

Department of Pathology (QL, FY, SL, JH, WL, HD), Hebei Medical University, Shijiazhuang, China.

Published: February 2014

AI Article Synopsis

Article Abstract

Inflammation is an important pathophysiological mechanism in diabetic nephropathy (DN). Tubular epithelial cell-myofibroblast transdifferentiation (TEMT), which can be induced by many cytokines, is an important event in DN. Oncostatin M (OSM), an inflammatory cytokine, can induce TEMT in vitro. The suppressors of cytokine signaling (SOCS) proteins are negative-feedback regulators of cytokine signaling. The purpose of this study was to investigate the role of SOCS in DN. The results demonstrated that overexpression of SOCS ameliorated proteinuria, the expression of α-SMA and OSM in tubular epithelial cells, and interstitial extracellular matrix accumulation in the renal tissue of CD-1 mice. In addition, our previous studies indicated that OSM induced TEMT by activating the JAK/STAT pathway, which could be inhibited by SOCS. These results indicate that overexpression of SOCS has a therapeutic effect in DN.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902095PMC
http://dx.doi.org/10.1369/0022155413512493DOI Listing

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