AI Article Synopsis
- A decapeptide model, L4PL4K, was studied to understand its helix-forming properties without solvent using advanced techniques like ion mobility mass spectrometry and electron capture dissociation.
- The research found that the resulting fragmentation patterns, mainly featuring b ions, suggest a relationship between helix formation and how the peptide behaves when it captures electrons.
- These findings indicate that the unique fragmentation patterns observed could serve as markers for the peptide's conformational dynamics during the study.
Article Abstract
The helix-forming character of a model decapeptide, L4PL4K, is determined in the absence of solvent using ion mobility mass spectrometry, electron capture dissociation and molecular mechanics simulations. Unusual ECD fragmentation patterns dominated by b ions are attributed to helix formation upon electron capture and as a signature of conformational dynamics.
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| http://dx.doi.org/10.1039/c3cc46356g | DOI Listing |
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