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Recent Neuropathology Concepts.
Toxicol Pathol
March 2025
Experimental Pathology Laboratories, Sterling, Virginia, USA.
The last session of the 2024 European Society of Toxicologic Pathology Congress was dedicated to recent neuro concepts, encompassing various topics including artificial intelligence (AI) applied to toxicologic pathology, new technologies for visualization and/or analysis of tissues, as well as specific case reports. Four presentations detailed the role of AI and computational pathology for toxicologic pathologists, usage of cryofluorescent tomography in neuropathology, blood-brain barrier organoids in early drug screening, and spatial transcriptomics in toxicologic pathology. In addition, there were two short presentations about a spontaneous brain lesion in Beagle dogs as well as central nervous system lesions related to adeno-associated virus vectors administration in various preclinical species.
View Article and Find Full Text PDFScientific highlights of the 8th world one health Congress, Cape Town, South Africa 2024.
One Health Outlook
March 2025
University of Veterinary Medicine, Hannover, 30559, Germany.
The 8th World One Health Congress took place in Cape Town, South Africa on 20-23 September 2024 to address all cross-sectoral and transdisciplinary aspects of the One Health paradigm, integrating human, animal, and environmental health. It brought together more than 1400 participants from 87 countries, and 400 speakers across 70 sessions. We summarize here the fourteen keynote lectures, which emphasized the need for a One Health approach to better integrate plant and agricultural health against food insecurity; the continuing challenges posed by antimicrobial resistance and emerging infectious threats; a paradigm shift towards health risk prevention; and approaches to further strengthen and expand the impact of the One Health movement.
View Article and Find Full Text PDFRemission of alcohol use disorder following traumatic brain injury with focal orbitofrontal cortex hemorrhage: case report and network mapping.
Commun Med (Lond)
March 2025
Neuropsychiatry program, Department of Psychiatry and Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Background: The orbitofrontal cortex (OFC) and its role in the regulation of urges/compulsion has been identified as a critical component of circuit-based addiction models. Building on such models, it was recently shown that brain lesions disrupting addictive behavior can be mapped to a common brain circuit.
Methods: We present a case of a 42-year-old woman with chronic treatment-refractory alcohol use disorder who experienced early remission following a traumatic brain injury (TBI) with focal left OFC intracerebral hemorrhage.
Impact of treatment for adolescent and young adults with essential thrombocythemia and polycythemia vera.
Leukemia
March 2025
Guy's and St. Thomas' NHS Foundation Trust, London, ENG, United Kingdom.
Essential thrombocythemia (ET) and polycythemia vera (PV) are rare in adolescent and young adult (AYA). These conditions, similar to those in older patients, are linked with thrombotic complications and the potential progression to secondary myelofibrosis (sMF). This retrospective study of ET and PV patients diagnosed before age 25 evaluated complication rates and impact of cytoreductive drugs on outcomes.
View Article and Find Full Text PDFERS Congress 2024: highlights from the Paediatrics Assembly.
ERJ Open Res
March 2025
Department of Pulmonary Medicine, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands.
https://bit.ly/40944lv.
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