AI Article Synopsis
- The study examined the antiallergic effects of dioscorins from different Dioscorea species using a mouse model induced with OVA allergies.
- Dioscorins were found to reduce allergic reactions by lowering serum IgE and histamine levels, while boosting IFN-γ and IgG2a levels.
- The findings suggest that dioscorins might help suppress allergic responses by balancing the Th1/Th2 immune response, as indicated by decreased IL-5 levels in treated mice.
Article Abstract
To study the biomedical functions of dioscorins isolated from various species of Dioscorea , we investigated their antiallergic potential using an OVA-induced allergy mouse model. All the dioscorins suppressed allergic reactions by decreasing the serum IgE and histamine levels. The serum IFN-γ and IgG2a levels increased in all the dioscorin-treated mice. The spleen cells from the dioscorin-treated mice also exhibited an up-regulation of IFN-γ secretion in response to ConA stimulation. Although dioscorins did not affect the IgG1 levels, the IL-5 levels decreased to basal levels in mice treated with dioscorins of D. alata or D. japonica and in most of the lymphoid cells of the dioscorin-treated mice in response to ConA stimulation. The decrease of IgE and histamine levels was concomitant with an increase in IFN-γ and IgG2a levels and with a decrease in IL-5 levels, suggesting that dioscorins suppressed the OVA-induced allergic reactions, possibly through modulating an imbalanced Th1/Th2 immune response.
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| http://dx.doi.org/10.1021/jf403480s | DOI Listing |
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