AI Article Synopsis
- A new method for creating substituted tetrahydrocarbolines has been developed using Ir-catalyzed intramolecular reactions.
- This process shows high selectivity for the desired molecule and works well under mild conditions.
- It also utilizes a chiral ligand that is easy to obtain, making the synthesis more practical.
Article Abstract
A highly enantioselective synthesis of substituted tetrahydrocarbolines via Ir-catalyzed Friedel-Crafts type intramolecular asymmetric allylic alkylation of 2-indolyl allyl carbonates has been developed. This strategy features excellent chemoselectivity and enantioselectivity, mild reaction conditions, and an easily accessed chiral ligand.
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| http://dx.doi.org/10.1021/ol4027717 | DOI Listing |
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