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Decoding NAD+ Metabolism in COVID-19: Implications for Immune Modulation and Therapy.
Vaccines (Basel)
December 2024
Department of Respiratory, Critical Care and Sleep Medicine, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China.
The persistent threat of COVID-19, particularly with the emergence of new variants, underscores the urgency for innovative therapeutic strategies beyond conventional antiviral treatments. Current immunotherapies, including IL-6/IL-6R monoclonal antibodies and JAK inhibitors, exhibit suboptimal efficacy, necessitating alternative approaches. Our review delves into the significance of NAD+ metabolism in COVID-19 pathology, marked by decreased NAD+ levels and upregulated NAD+-consuming enzymes such as CD38 and poly (ADP-ribose) polymerases (PARPs).
View Article and Find Full Text PDFA Comparative Review of Alternative Fucoidan Extraction Techniques from Seaweed.
Mar Drugs
January 2025
Institute for Bioengineering, The School of Engineering, The University of Edinburgh, Edinburgh EH9 3DW, UK.
Fucoidan is a sulfated polysaccharide found in brown seaweed. Due to its reported biological activities, including antiviral, antibacterial and anti-inflammatory activities, it has garnered significant attention for potential biomedical applications. However, the direct relationship between fucoidan extracts' chemical structures and bioactivities is unclear, making it extremely challenging to predict whether an extract will possess a given bioactivity.
View Article and Find Full Text PDFResearch Progress on the Chemical Constituents and Pharmacological Effects of Thunb and a Predictive Analysis of Quality Markers.
Curr Issues Mol Biol
December 2024
College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China.
() is widely used in respiratory disease control as an important heat-clearing and detoxifying traditional Chinese medicine. It effectively clears away heat and toxins, eliminates carbuncles, and drains pus, and it is diuretic and detoxicating. The aim of this study is to review the botany, chemical composition, pharmacological effects, and quality control of to establish a better-quality evaluation system.
View Article and Find Full Text PDFA Review of the Antiviral Activity of Berberine.
Curr Drug Discov Technol
January 2025
Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Berberine is an isoquinoline alkaloid with strong pharmacological activity such as analgesic, antioxidant, neuroprotective, antivirus, anti-inflammatory, anti-seizure, anti-obesity, and hypolipidemic effects. Accumulated evidence indicates berberine plays an inhibitory role against infection of numerous viruses, including human immunodeficiency virus, respiratory syncytial virus, hepatitis C virus, human papillomavirus, human cytomegalovirus, and influenza virus. Berberine's antiviral action has shown promise, making it a viable option for synergistically enhancing the inhibitory effect of current antiviral medicines.
View Article and Find Full Text PDFMolecular mechanisms behind the anti corona virus activity of small metal oxide nanoparticles.
Nanoscale
January 2025
Department of Molecular Science, BioCenter, Swedish University of Agricultural Sciences, Box 7015, 75007 Uppsala, Sweden.
The recent COVID-19 pandemic has set a strong quest for advanced understanding of possible tracks in abating and eliminating viral infections. In the view that several families of "pristine" small oxide nanoparticles (NPs) have demonstrated viricidal activity against SARS-CoV-2, we studied the effect of two NPs, with presumably different reactivity, on two viruses aiming to evaluate two "primary suspect" routes of their antiviral activity, either specific blocking of surface proteins or causing membrane disruption. The chosen NPs were non-photoactive 3.
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