AI Article Synopsis
- 90Y-microspheres therapy is an effective treatment for liver tumors, but requires a preliminary 99mTc-MAA simulation to assess potential risks.
- A study on four patients showed that the lung shunt fraction (LSF) changed significantly up to five hours post-injection of 99mTc-MAA, affecting accuracy.
- Longer intervals between injection and scanning can lead to overestimating LSF, potentially resulting in reduced treatment dosages or cancellation, so shorter intervals are recommended.
Article Abstract
90Y-microspheres therapy is used to treat selected patients with primary or metastatic liver tumors in a safe and effective way. As a preparation for 90Y-microspheres treatment, a 99mTc-macroaggregated albumin (99mTc-MAA) simulation procedure is essential to evaluate particle shunting to the lung or gastrointestinal tract. We investigated the effect of interval between injection of 99mTc-MAA and time of scanning on the lung shunt fraction (LSF). In 4 patients with secondary hepatic malignancies who underwent repeated whole-body scintigraphy up to 5 hours after injection of 99mTc-MAA, a marked change in LSF was observed. It appears that tracer degradation leads to an important overestimation of LSF at later time points. An overestimation of LSF can lead to dose reduction or canceling of the planned 90Y-microspheres treatment. It is concluded that the interval between injection and scanning should be kept as short as possible.
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| http://dx.doi.org/10.1097/RLU.0000000000000241 | DOI Listing |
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