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The Potential Role of Dietary Polyphenols in the Prevention and Treatment of Acute Leukemia.

Nutrients

November 2024

VAS-European Independent Foundation in Angiology/Vascular Medicine, Via GB Grassi 74, 20157 Milan, Italy.

Acute leukemia is a prevalent cancer worldwide and is classified into two distinct forms. Currently, various therapies have been developed for this disease; however, the issues of recurrence, resistance to treatment, and adverse effects require the exploration of novel treatments. Polyphenols, classified into four categories, are secondary metabolites originating from plants that demonstrate diverse metabolic features such as anticancer, anti-inflammatory, and antioxidant activities.

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Intermittent claudication is the most common symptom of Peripheral Arterial Disease (PAD) and is associated with decreased quality of life (QoL) due to walking impairment. The level of threat attributed to the disease affects QoL and physical activity. This study explores beliefs and illness drawings, and their relationship with quality of life and physical activity in patients undergoing conservative treatment for PAD.

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Article Synopsis
  • Buerger's disease (BD) is a serious condition that requires early diagnosis for effective treatment, but there’s no universally accepted method for diagnosing it due to varied criteria used by different vascular centers.
  • A recent Delphi Consensus Study highlighted the lack of consensus on BD diagnostic criteria, particularly beyond the requirement of a history of smoking, making it hard to compare patient outcomes globally.
  • The VAS-European Independent Foundation has proposed that a definitive BD diagnosis should include a history of smoking, typical angiographic and histopathological features, and suggests using a combination of major and minor criteria for suspected diagnoses, with validation studies currently in progress.
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Socio-economic determinants of health (SDoH) include various nonmedical factors in the socio-economic sphere with a potentially significant impact on health outcomes. Their effects manifest through several mediators/moderators (behavioral characteristics, physical environment, psychosocial circumstances, access to care, and biological factors). Various critical covariates (age, gender/sex, race/ethnicity, culture/acculturation, and disability status) also interact.

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