AI Article Synopsis
- The study investigates the effects of maternal cytokine surges, particularly interleukin-6 (IL-6), on the development of adult neural stem cell pools in offspring.
- It finds that exposure to elevated IL-6 during fetal development leads to an increased number of neural precursors in the adult forebrain and disrupts olfactory neurogenesis.
- This research reveals a specific self-renewal pathway for neural stem cells that may be influenced by maternal cytokine levels, suggesting that such maternal health issues can have lasting impacts on the progeny’s brain development.
Article Abstract
The mechanisms that regulate the establishment of adult stem cell pools during normal and perturbed mammalian development are still largely unknown. Here, we asked whether a maternal cytokine surge, which occurs during human maternal infections and has been implicated in cognitive disorders, might have long-lasting consequences for neural stem cell pools in adult progeny. We show that transient, maternally administered interleukin-6 (IL-6) resulted in an expanded adult forebrain neural precursor pool and perturbed olfactory neurogenesis in offspring months after fetal exposure. This increase is likely the long-term consequence of acute hyperactivation of an endogenous autocrine/paracrine IL-6-dependent self-renewal pathway that normally regulates the number of forebrain neural precursors. These studies therefore identify an IL-6-dependent neural stem cell self-renewal pathway in vivo, and support a model in which transiently increased maternal cytokines can act through this pathway in offspring to deregulate neural precursor biology from embryogenesis throughout life.
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| http://dx.doi.org/10.1016/j.stem.2013.10.002 | DOI Listing |
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