Atherosclerosis is driven by the release of cytokines from macrophages, and the β isoform of interleukin-1 (IL-1β) is a prime suspect in disease progression. Freigang et al. (2013) now suggest that IL-1α, a close relative, is selectively induced by fatty acids independent of the inflammasome to promote vascular inflammation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869622 | PMC |
| http://dx.doi.org/10.1016/j.cmet.2013.10.009 | DOI Listing |
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