Lacrimal gland amyloidosis: a clinicopathological correlation of a rare disorder and review of literature.

Purpose: To report a rare case of primary localized lacrimal gland amyloidosis and present a detailed review of the literature.

Method: A 72-year-old woman presented with painless mass of 3 years' duration in the supero-temporal left orbit arising from the lacrimal gland. The patient underwent an excision biopsy and a further systemic workup and was diagnosed to have a primary, localized lacrimal gland amyloidosis. Only 18 cases have been reported in the literature. Based on the published cases and the present case, the clinical profiles, radiological features, and outcomes of this infrequent entity are discussed.

Conclusion: Lacrimal gland amyloidosis, although rare, should be a differential diagnosis for a lacrimal gland mass, especially in elderly females. Review of the literature provides a clearer understanding of the presentations and management.