AI Article Synopsis
- This study examines olfactory function in various mouse models of Parkinson's disease (PD) to understand early pathology, particularly considering olfactory impairment that occurs before motor symptoms.
- Results indicate that certain genetic models and intraperitoneal MPTP treatment do not exhibit olfactory impairment, while a specific transgenic mouse model shows mobility issues affecting behavioral testing.
- Importantly, it was found that intranasal application of MPTP can lead to functional damage in the olfactory epithelium, suggesting a possible mechanism for olfactory deficits in PD.
Article Abstract
Various genetic or toxin-induced mouse models are frequently used for investigation of early PD pathology. Although olfactory impairment is known to precede motor symptoms by years, it is not known whether it is caused by impairments in the brain, the olfactory epithelium, or both. In this study, we investigated the olfactory function in three genetic Parkinson's disease (PD) mouse models and mice treated with MPTP intraperitoneally and intranasally. To investigate olfactory function, we performed electro-olfactogram recordings (EOGs) and an olfactory behavior test (cookie-finding test). We show that neither a parkin knockout mouse strain, nor intraperitoneal MPTP treated animals display any olfactory impairment in EOG recordings and the applied behavior test. We also found no difference in the responses of the olfactory epithelium to odorants in a mouse strain over-expressing doubly mutated α-synuclein, while this mouse strain was not suitable to test olfaction in a cookie-finding test as it displays a mobility impairment. A transgenic mouse expressing mutated α-synuclein in dopaminergic neurons performed equal to control animals in the cookie-finding test. Further we show that intranasal MPTP application can cause functional damage of the olfactory epithelium.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813626 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0077509 | PLOS |
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