A new approach to the total synthesis of (-)-epimyrtine has been developed from D-alanine. The key step to access the enantiopure pyridone intermediate was achieved by a gold-mediated cyclization. Finally, various transformations afforded the natural product in a few steps and good overall yield.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817515 | PMC |
| http://dx.doi.org/10.3762/bjoc.9.242 | DOI Listing |
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