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| http://dx.doi.org/10.1371/journal.pbio.1001693 | DOI Listing |
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Apicoplast-Resident Processes: Exploiting the Chink in the Armour of Parasites.
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May 2024
Department of Biochemistry, Covenant University, Ota, Nigeria.
The discovery of a relict plastid, also known as an apicoplast (apicomplexan plastid), that houses housekeeping processes and metabolic pathways critical to parasites' survival has prompted increased research on identifying potent inhibitors that can impinge on apicoplast-localised processes. The apicoplast is absent in humans, yet it is proposed to originate from the eukaryote's secondary endosymbiosis of a primary symbiont. This symbiotic relationship provides a favourable microenvironment for metabolic processes such as haem biosynthesis, Fe-S cluster synthesis, isoprenoid biosynthesis, fatty acid synthesis, and housekeeping processes such as DNA replication, transcription, and translation, distinct from analogous mammalian processes.
View Article and Find Full Text PDFA new chink in cancer's armor: Unleashing cell death by selective PP5 inhibition.
Cell Chem Biol
October 2023
Department of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC 28223, USA. Electronic address:
Serine/threonine protein phosphatases play a significant role in the survival and propagation of multiple cancers. In this issue of Cell Chemical Biology, Ahanin et al. demonstrate that protein phosphatase 5 (PP5) dephosphorylates and inactivates the cell death effector protein FADD independently of Hsp90, and they identify a selective PP5 inhibitor as a new therapeutic strategy for renal cancer.
View Article and Find Full Text PDFApproaches for targeting the mycobactin biosynthesis pathway for novel anti-tubercular drug discovery: where we stand.
Expert Opin Drug Discov
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Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi, India.
Introduction: Several decades of antitubercular drug discovery efforts have focused on novel antitubercular chemotherapies. However, recent efforts have greatly shifted toward countering extremely/multi/total drug-resistant species. Targeting the conditionally essential elements inside Mycobacterium is a relatively new approach against tuberculosis and has received lackluster attention.
View Article and Find Full Text PDFFinding a chink in the armor: Update, limitations, and challenges toward successful antivirals against flaviviruses.
PLoS Negl Trop Dis
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Infection and Immunity Research Strength, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia.
Flaviviruses have caused large epidemics and ongoing outbreaks for centuries. They are now distributed in every continent infecting up to millions of people annually and may emerge to cause future epidemics. Some of the viruses from this group cause severe illnesses ranging from hemorrhagic to neurological manifestations.
View Article and Find Full Text PDFIntroductory Chapter: The Importance of Heat Shock Proteins in Survival and Pathogenesis of the Malaria Parasite Plasmodium falciparum.
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September 2021
Biochemistry and Molecular Biology (BiMoBi), iFZ, Justus-Liebig University Gießen, Gießen, Germany.
Malaria did not die with the end of the age of western colonization but is still a major public health issue in large parts of the world. Despite repeated and concerted efforts to eradicate this disease, it has proved remarkably resilient, and constant vigilance and continuous research are required to discover new chinks in the parasite's armor and alleviate the suffering at both the individual and societal levels. A deeper understanding of the fundamental processes underlying parasite survival, propagation, virulence, and ability to cause disease is the key to the development of desperately needed new therapies and prophylactic drugs.
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