A young man with altered mental status and new-onset seizures.

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Richard S. Cassa is a senior PA in the department of neurology, division of acute neurosciences at New York Presbyterian Hospital-Cornell in New York City. Axel J. Rosengart is director of neurocritical care and an associate professor of neurology, neuroscience, and neurosurgery at Weill Cornell Medical College in New York City. The authors have indicated no relationships to disclose relating to the content of this article.

Published: October 2013

Signs and symptoms of a subacute, progressive, imaging-negative encephalopathy can be misdiagnosed as a neuropsychiatric or progressive neurodegenerative disorder. However, encephalopathies often can be reversed if the autoimmune component is recognized early through a careful history and diagnostic testing, including cerebrospinal fluid analysis for antibodies.

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http://dx.doi.org/10.1097/01.JAA.0000435005.09599.79DOI Listing

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