Appropriate placement of the keyhole at the transverse and sigmoid sinus (T/S) junction is important for performance of safe and accurate lateral suboccipital craniotomy with minimum bone loss. Here, we report a method for predicting the position of the T/S junction and investigate the relationship between the T/S junction and asterion. The subjects were 88 patients treated surgically via a lateral suboccipital approach. These cases included 78 acoustic neuromas, 4 meningiomas, 1 trigeminal schwannoma, 1 epidermoid cyst, 2 trigeminal neuralgias, and 1 hemifacial spasm. To expose the T/S junction, we usually place the keyhole lateral to asterion by a half diameter of the burr hole. The distance of the T/S junction from asterion was investigated using three-dimensional computed tomography (3DCT) images. We investigated the differences between the actual and predicted positions of the T/S junction based on skull landmarks, and we compared our method with other literature methods. The mean distances were 5.7 mm caudal and 6.6 mm lateral. The difference between the actual and predicted positions was significantly smaller in our approach compared to other methods. Placing the keyhole lateral to a provisional burr hole just caudal to asterion and lateral by half the diameter of the burr hole was useful for exposure of the T/S junction. The best approach is to use preoperative 3DCT, but this may be limited by equipment problems, emergency cases, or allergy to contrast medium. Determination of the appropriate keyhole position with reference to skull landmarks is a universally useful method.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533474 | PMC |
http://dx.doi.org/10.2176/nmc.oa2013-0020 | DOI Listing |
bioRxiv
December 2024
Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA.
Immune exclusion inhibits anti-tumor immunity and response to immunotherapy, but its mechanisms remain poorly defined. Here, we demonstrate that Trophoblast Cell-Surface Antigen 2 (TROP2), a key target of emerging anti-cancer Antibody Drug Conjugates (ADCs), controls barrier-mediated immune exclusion in Triple-Negative Breast Cancer (TNBC) through Claudin 7 association and tight junction regulation. TROP2 expression is inversely correlated with T cell infiltration and strongly associated with outcomes in TNBC.
View Article and Find Full Text PDFNanophotonics
September 2024
Centre de Nanosciences et de Nanotechnologies, CNRS, Université Paris-Saclay, 91120 Palaiseau, France.
Multimode silicon photonics, leveraging mode-division multiplexing technologies, offers significant potential to increase capacity of large-scale multiprocessing systems for on-chip optical interconnects. These technologies have implications not only for telecom and datacom applications, but also for cutting-edge fields such as quantum and nonlinear photonics. Thus, the development of compact, low-loss and low-crosstalk multimode devices, in particular mode exchangers, is crucial for effective on-chip mode manipulation.
View Article and Find Full Text PDFSci Rep
June 2024
Department of Physics, Tamkang University, Tamsui Dist., New Taipei City, 251301, Taiwan.
We exploit bias polarity dependent low-frequency noise (LFN) spectroscopy to investigate charge transport dynamics in ultra-thin AlO-based magnetic tunnel junctions (MTJs) with bipolar resistive switching (RS). By measuring the noise characteristics across the entire bias voltage range of bipolar RS, we find that the voltage noise level exhibits an bias polarity dependence. This distinct feature is intimately correlated with reconfiguring of the inherently existing oxygen vacancies ( ) in as-grown MTJ devices during the SET and RESET switching processes.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
March 2024
Biophysics Program, Stanford University, Stanford, CA 94305.
Coronavirus genomes sequester their start codons within stem-loop 5 (SL5), a structured, 5' genomic RNA element. In most alpha- and betacoronaviruses, the secondary structure of SL5 is predicted to contain a four-way junction of helical stems, some of which are capped with UUYYGU hexaloops. Here, using cryogenic electron microscopy (cryo-EM) and computational modeling with biochemically determined secondary structures, we present three-dimensional structures of SL5 from six coronaviruses.
View Article and Find Full Text PDFbioRxiv
November 2023
Biophysics Program, Stanford University, Stanford, CA, USA.
Coronavirus genomes sequester their start codons within stem-loop 5 (SL5), a structured, 5' genomic RNA element. In most alpha- and betacoronaviruses, the secondary structure of SL5 is predicted to contain a four-way junction of helical stems, some of which are capped with UUYYGU hexaloops. Here, using cryogenic electron microscopy (cryo-EM) and computational modeling with biochemically-determined secondary structures, we present three-dimensional structures of SL5 from six coronaviruses.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!