We show the potential of the nanosilicon structure of the frustules of a typical diatom, Cymatopleura sp., as a new vehicle for drugs. The basic diatom nanostructure is a lattice of SiO2, and computerized methods in a dock project have identified the most likely and the best drug types to load into such a structure.
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http://dx.doi.org/10.2147/NSA.S8378 | DOI Listing |
Soft comput
September 2024
School of Computer Science and Engineering, Hunan University of Information Technology, Changsha, 410151 Hunan China.
[This retracts the article DOI: 10.1007/s00500-023-08073-4.].
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Ernst Strüngmann Institute, Frankfurt am Main 60528, Germany.
The dynamics of neuronal systems are characterized by hallmark features such as oscillations and synchrony. However, it has remained unclear whether these characteristics are epiphenomena or are exploited for computation. Due to the challenge of selectively interfering with oscillatory network dynamics in neuronal systems, we simulated recurrent networks of damped harmonic oscillators in which oscillatory activity is enforced in each node, a choice well supported by experimental findings.
View Article and Find Full Text PDFPlant Foods Hum Nutr
January 2025
Qinghai Provincial Key Laboratory of Tibetan Medicine Research and CAS Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Science, Xining, 810008, P.R. China.
NAFLD is one of the most common and rapidly increasing liver diseases. Procyanidin C1 and procyanidin C2, B-type trimeric procyanidins, show beneficial effects on regulating lipid metabolism. However, the mechanism underlying these effects remain elusive.
View Article and Find Full Text PDFBull Math Biol
January 2025
Department of Biology, Faculty of Science, Kyushu University, 744 Motooka, Nishi-Ku, Fukuoka, 819-0395, Japan.
Mathematical models of immune responses have traditionally focused on adaptive immunity and pathogen-immune dynamics. However, recent advances in immunology have highlighted the critical role of innate immunity. In response to physical damage or pathogen attacks, innate immune cells circulating throughout the body rapidly migrate from blood vessels and accumulate at the site of injury, triggering inflammation.
View Article and Find Full Text PDFBull Math Biol
January 2025
Department of Mathematics, Vivekananda College, Kolkata, West Bengal, 700063, India.
The extinction of species is a major threat to the biodiversity. Allee effects are strongly linked to population extinction vulnerability. Emerging ecological evidence from numerous ecosystems reveals that the Allee effect, which is brought on by two or more processes, can work on a single species concurrently.
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