In many fume hood applications, pollutant-generation devices are tall. Human operators of a fume hood must stand close to the front of the hood and lift up their hands to reach the top opening of the tall tank. In this situation, it is inconvenient to access the conventional hood because the sash acts as a barrier. Also, the bluff-body wake in front of the operator's chest causes a problem. By using laser-assisted smoke flow visualization and tracer-gas test methods, the present study examines a sashless inclined air-curtain (sIAC) fume hood for tall pollutant-generation tanks, with a mannequin standing in front of the hood face. The configuration of the sIAC fume hood, which had the important element of a backward-inclined push-pull air curtain, was different from conventional configurations. Depending on suction velocity, the backward-inclined air curtain had three characteristic modes: straight, concave, and attachment. A large recirculation bubble covering the area--from the hood ceiling to the work surface--was formed behind the inclined air curtain in the straight and concave modes. In the attachment mode, the inclined air curtain was attached to the rear wall of the hood, about 50 cm from the hood ceiling, and bifurcated into up and down streams. Releasing the pollutants at an altitude above where the inclined air curtain was attached caused the suction slot to directly draw up the pollutants. Releasing pollutants in the rear recirculation bubble created a risk of pollutants' leaking from the hood face. The tracer-gas (SF6) test results showed that operating the sIAC hood in the attachment mode, with the pollutants being released high above the critical altitude, could guarantee almost no leakage, even though a mannequin was standing in front of the sashless hood face.
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http://dx.doi.org/10.1080/15459624.2013.831984 | DOI Listing |
J Org Chem
January 2025
Department of Chemistry and Chemical Biology, Indian Institute of Technology (Indian School of Mines), Dhanbad 826004, India.
An efficient deuteration method through the ex situ generation of D for the reductive deuteration of biologically significant α-substituted acrylic acids and enamide derivatives is reported. This method was successfully applied to the synthesis of deuterated analogs of marketed NSAIDs such as ibuprofen, flurbiprofen, and naproxen. Additionally, it facilitates late-stage deuteration of enamides and -vinylated drugs.
View Article and Find Full Text PDFJ Occup Environ Hyg
October 2024
School of the Environment, Faculty of Science, The University of Queensland, Brisbane, Queensland, Australia.
Exposure to chlorine dioxide by staff working in a gnotobiotic mouse facility at an Australian research institute was measured to determine whether current controls were sufficient to ensure their exposure remains below the current Australian workplace exposure standard. A combination of workplace surveys, interviews with workers, and personal sampling was undertaken to understand the workplace, identify higher-risk tasks, and measure the concentration of chlorine dioxide in the air where the workers conduct routine tasks involving the use of a chlorine dioxide-based disinfectant. Personal sampling utilized the validated Occupational Safety and Health Administration (OSHA) method ID-202, with minor alterations.
View Article and Find Full Text PDFMagn Reson Chem
July 2024
Pivotal and Commercial Drug Substance Technologies, Process Development, Amgen Inc., Thousand Oaks, California, USA.
The discovery of new ceramic materials containing Ba-La-Cu oxides in 1986 that exhibited superconducting properties at high temperatures in the range of 35 K or higher, recognized with the Nobel Prize in Physics in 1987, opened a new world of opportunities for nuclear magnetic resonance (NMRs) and magnetic resonance imaging (MRIs) to move away from liquid cryogens. This discovery expands the application of high temperature superconducting (HTS) materials to fields beyond the chemical and medical industries, including electrical power grids, energy, and aerospace. The prototype 400-MHz cryofree HTS NMR spectrometer installed at Amgen's chemistry laboratory has been vital for a variety of applications such as structure analysis, reaction monitoring, and CASE-3D studies with RDCs.
View Article and Find Full Text PDFParasit Vectors
February 2024
Bill & Melinda Gates Foundation, 500 5th Ave N, Seattle, WA, 98109, USA.
Background: Efforts to evaluate the residual efficacy of new indoor residual spraying (IRS) formulations have identified limitations with the industry standard laboratory sprayer, the Potter Spray Tower (PT). Calibrating the PT can be time-consuming, and the dosing of surfaces may not be as accurate or uniform as previously assumed.
Methods: To address these limitations, the Micron Horizontal Track Sprayer with Spray Cabinet (TS) was developed to provide higher efficiency, ease of operation and deposition uniformity equal to or better than the PT.
Adv Mater Technol
August 2023
Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114.
Microfluidic devices have been used for decades to isolate cells, viruses, and proteins using on-chip immunoaffinity capture using biotinylated antibodies, proteins, or aptamers. To accomplish this, the inner surface is modified to present binding moieties for the desired analyte. While this approach has been successful in research settings, it is challenging to scale many surface modification strategies.
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