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| http://dx.doi.org/10.1073/pnas.1317472110 | DOI Listing |
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SMALL BUT MIGHTY: CHARACTERIZATION OF VB_SPY_7, A LYTIC PHAGE TARGETING STREPTOCOCCUS PYOGENES.
Georgian Med News
October 2024
1G. Eliava Institute of Bacteriophage, Microbiology and Virology, Tbilisi, Georgia.
The emergence of antibiotic-resistant pathogens necessitates alternative therapies for treating microbial infections, especially in the oral cavity and upper respiratory tract. Our team has developed Phage Pastilles, a controlled-release formulation containing bacteriophages that target common pathogens, including Streptococcus pyogenes, Streptococcus salivarius, Staphylococcus aureus, Enterococcus faecalis, and E. coli.
View Article and Find Full Text PDFSmall but mighty: nanoemulsion particle size dictates bone regeneration potential of FTY720.
Nanoscale
December 2024
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
The burgeoning field of nano-bone regeneration is yet to establish a definitive optimal particle size for nanocarriers. This study investigated the impacts of nanocarrier's particle size on the bone regeneration efficacy of fingolimod (FTY720)-loaded nanoemulsions. Two distinct particle sizes (60 and 190 nm, designated as NF60 and NF190, respectively) were produced using low-energy and high-energy emulsion techniques, maintaining a consistent surfactant, co-surfactant, and oil.
View Article and Find Full Text PDF"Small but mighty" - A radiologists' primer for ultrasound imaging of the smaller peripheral nerves.
Skeletal Radiol
December 2024
Royal Orthopedic Hospital, Birmingham, UK.
Peripheral nerve imaging is a powerful tool in evaluating peripheral neuropathy. This review aims to provide an overview of the anatomy, clinical significance and pathologies of small peripheral nerves, typically less than 2 mm in diameter. High frequency ultrasound probes offer the best assessment of these nerves whilst permitting real-time clinical correlation, while the role of MRI is inherently limited by spatial resolution constraints and the lack of patient contact.
View Article and Find Full Text PDFSmall but mighty: targeted antifungal liposomes of a smaller size are superior in treating cryptococcal meningitis.
mBio
December 2024
Department of Plant Biology, University of Georgia, Athens, Georgia, USA.
Unlabelled: Cryptococcal meningoencephalitis (CME) is deadly. CME is responsible for 19% of deaths in AIDS patients, and its global mortality is greater than 60%. The recommended CME therapy requires amphotericin B (AmB), a fungicidal drug targeting fungal ergosterol.
View Article and Find Full Text PDFInfection Prevention: The Small but Mighty Teams in Health Care.
HCA Healthc J Med
October 2024
HCA Healthcare Clinical Services Group, Nashville, TN.
Description Infection prevention is a team within health care facilities and systems whose members are vital to reducing and mitigating patient harm secondary to infectious disease. Infection preventionists are subject matter experts who reside in the quality department and are responsible for multiple areas beyond infectious disease spread. They assist nursing teams, employee health programs, and epidemiologists in decreasing the spread of illness.
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