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A study on neurodevelopmental outcomes in infants with congenital hypothyroidism highlights the importance of periodic developmental assessment.
J Pediatr (Rio J)
January 2025
University of Amsterdam, Emma Children's Hospital Amsterdam University Medical Centers, Department of Pediatric Endocrinology, Amsterdam, The Netherlands; Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands; European Reference Network on Rare Endocrine Conditions (Endo-ERN), Amsterdam, The Netherlands.
Introduction: The objective of our study was to determine the prevalence of a delayed thyroid-stimulating hormone (TSH) rise in infants with congenital hypothyroidism (CH) born in Indiana. Additionally, we sought to determine whether there are differences in clinical or demographic factors associated with this delayed cohort compared to those seen in infants detected early.
Methods: Newborn screen (NBS) results were collected for all cases of CH diagnosed between 2012-2022.
Clinical Insight into Congenital Hypothyroidism Among Children.
Children (Basel)
January 2025
Department of Pediatrics, Division of Pediatric Endocrinology, Izmir Faculty of Medicine, University of Health Sciences, 35210 Izmir, Turkey.
Molecular, genetic, and technological advances have led to increased knowledge regarding neonatal thyroid hormone metabolism disorders. Maternal and fetal hypothyroidism, which can cause psychomotor dysfunction syndromes or low IQ levels, can lead to brain damage, reduced fetal growth and incidental fetal death. The treatment of congenital hypothyroidism detected by screening programs performed during the neonatal period provides normalization of growth, IQ levels, and the physical, mental, and motor development of infants.
View Article and Find Full Text PDFNewborn screening and the screening laboratory: past, present and future.
Eur Thyroid J
January 2025
A Heijboer, Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam, 1105AZ, Netherlands.
Thyroid hormone (TH) is essential for brain development in utero and during the first two to three years of life. The negative effects of TH deficiency on brain development are irreversible. Early detection of TH deficiency in neonates (congenital hypothyroidism (CH) through newborn screening (NBS)) allows for early treatment, thereby preventing brain damage.
View Article and Find Full Text PDFSerum Neudesin Levels in Patients with Congenital Hypothyroidism.
J Clin Res Pediatr Endocrinol
January 2025
Cam and Sakura City Hospital Department of Pediatrics, Division of Pediatric Endocrinology, Istanbul, Turkey.
Objectives: Neudesin is a newly discovered protein mainly secreted from adipose tissue and the brain. It plays a role as a neurotrophic factor in the brain and a negative regulator of energy expenditure. Neurodevelopmental delay and cognitive dysfunction are common features in cases with congenital hypothyroidism (CH) without treatment.
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