Background/aims: There is emerging evidence of gabapentin and pregabalin (gabapentinoid) abuse, particularly in the substance misuse population, and some suggestion of gabapentinoids being abused alongside methadone.
Methods: A questionnaire-based survey was carried out in six substance misuse clinics, looking for evidence of gabapentinoid abuse.
Results: 22% (29/129) of respondents admitted to abusing gabapentinoids, and of these, 38% (11/29) abused gabapentinoids in order to potentiate the 'high' they obtained from methadone.
Conclusions: Gabapentinoid abuse along with methadone has not previously been described. These findings are of relevance to clinicians working within both substance misuse services and chronic pain services.
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http://dx.doi.org/10.1159/000355268 | DOI Listing |
Int J Pharm Pract
December 2024
Department of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, University of Jordan, Amman, Jordan.
Objectives: Pregabalin abuse is increasing in prevalence and is associated with significant harm. This study aimed to assess community pharmacists' perceptions of pregabalin abuse and their recommendations to address this issue.
Methods: This was a descriptive cross-sectional study conducted in the Omdurman locality, Khartoum in 2022.
Spine (Phila Pa 1976)
November 2024
Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
J Surg Res
November 2024
Division of Vascular Surgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
Introduction: This study assesses the association of preoperative use of gabapentinoids (GBPs) with postoperative risk of opioid-related disorders in peripheral artery disease patients undergoing lower extremity bypass operation.
Methods: This is a retrospective propensity score-matched analysis of patients undergoing peripheral artery bypass in TriNetX, a multicenter national database. Two study groups were constituted based on the preoperative history of prescribed GBPs.
J Clin Med
October 2024
Physiology Section, Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, University of Barcelona, 08028 Barcelona, Spain.
: Since 2008, several cases of pregabalin abuse have been reported to the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). Despite this evidence, gabapentinoids are increasingly being prescribed. Moreover, pregabalin is being used in a recreational setting for its dissociative effects and euphoria.
View Article and Find Full Text PDFInt J Drug Policy
November 2024
Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. Electronic address:
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