The meteorological and environmental data including visibility, SO2, NO2 and PM10 were collected in four major megacities (Beijing, Shanghai, Guangzhou and Chengdu) in the years 2006-2009. Based on the data, seasonal and annual variations of the haze frequency and the key impact factors were discussed. The results indicated that the highest frequencies of haze occurred in summer, winter, spring and autumn for Beijing, Shanghai, Guangzhou and Chengdu, respectively. The trends of haze frequency decreased in Beijing and Guangzhou, while increased in Shanghai and Chengdu during the studied period. The PM10 concentration and relative humidity were the key factors for visibility degradation in the four megacities. The variation of visibility was sensitive to relative humidity in Beijing, to PM10 in Shanghai and Guangzhou, and to both in Chengdu.
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Digit Health
January 2025
School of Public Management, East China Normal University, Shanghai, China.
Objectives: This study aims to investigate whether social networks and physical exercise mediate the relationship between new and constant use of intelligent virtual assistants (IVAs) and cognitive function in older adults in China and explore the potential differences across living arrangements and education levels.
Methods: This study utilized nationally representative longitudinal data from 2018 to 2020, including a sample of 8343 older adults aged 60-80. A path-analytic model was employed to examine the relationship between IVAs use and cognitive function, as well as the mediating roles of social networks and physical exercise.
Biomark Med
January 2025
Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai, China.
Objective: This study aims to explore the association between arginase 1 (ARG1) genetic variation and susceptibility to type 2 diabetes (T2DM) vascular complications, a primary cause of morbidity and mortality in diabetics.
Methods: ARG1, a risk gene for cardiovascular disease, was identified from GEO datasets GSE22255 and GSE58294. The ENCODE database identified four candidate single-nucleotide polymorphism (SNP) loci.
Sci Rep
January 2025
School of Mathematics and Statistics, Central South University, Changsha, 410083, China.
The coronavirus disease 2019 (COVID-19) interventions in interrupting transmission have paid heavy losses politically and economically. The Chinese government has replaced scaling up testing with monitoring focus groups and randomly supervising sampling, encouraging scientific research on the COVID-19 transmission curve to be confirmed by constructing epidemiological models, which include statistical models, computer simulations, mathematical illustrations of the pathogen and its effects, and several other methodologies. Although predicting and forecasting the propagation of COVID-19 are valuable, they nevertheless present an enormous challenge.
View Article and Find Full Text PDFEur Respir J
January 2025
Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Objective: To compare the effectiveness and safety of tofacitinib (TOF) calcineurin inhibitor (CNI) as initial immunosuppressive regimen for anti-melanoma differentiation-associated gene 5-positive dermatomyositis with interstitial lung disease (MDA5+DM-ILD).
Methods: Adult Chinese patients with newly-diagnosed MDA5+DM-ILD (ILD course<3 months) from five tertiary referral centres between April 2014 and January 2023 were included for this retrospective cohort study. The primary effectiveness endpoint was lung transplantation-free survival within 1 year.
Lung Cancer
January 2025
Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, PR China. Electronic address:
Background: In the phase 3 ORIENT-11 study, sintilimab plus pemetrexed-platinum provided statistically significant longer overall survival and progression-free survival versus placebo plus pemetrexed-platinum as first-line treatment in patients with locally advanced or metastatic non-squamous non-small cell lung cancer (NSCLC). Here, we report the patient-reported outcomes (PRO) analysis findings in ORIENT-11.
Methods: PROs were measured using the European Organization for Research and Treatment of Cancer Quality of Life of Cancer Patients Questionnaire Core 30 items (EORTC QLQ-C30) and the Lung Cancer Symptom Scale (LCSS) questionnaire.
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