AI Article Synopsis
- The study measured fasting plasma levels of large neutral amino acids and L-tryptophan in 13 healthy volunteers over five mornings and repeated it three months later.
- Results showed typical ranges for these measurements, with notable differences between males and females, as well as significant daily variations within individuals.
- The researchers concluded that while there were identifiable average levels over three months, the individual variability is too high to define a single value as characteristic for a person, which is important for future studies on conditions like depression.
Article Abstract
Fasting plasma levels of the large neutral amino acids (LNAA;L-forms) andL-tryptophan (TRP) ratios were determined in thirteen healthy volunteers (7 males, 6 females) on five consecutive mornings, and the same procedure was repeated for each individual three months later. We found characteristic overall ranges for the parameters studied, and, in addition to certain differences between the sexes, considerable inter- and intraindividual daily variations. Although the individuals showed statistically identifiable mean levels that, in the majority of subjects, were maintained over a period of three months, it is concluded that the degree of intraindividual variability does not allow us to regard a single value as "characteristic" for a given individual. This should be borne in mind in particular in follow-up studies of plasma LNAA in patients with, for example, depressive disorders.
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| http://dx.doi.org/10.1007/BF00805988 | DOI Listing |
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