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Products of methotrexate during chlorination.
J Environ Sci (China)
May 2017
Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Research Center for Preventive Medicine, Beijing 100013, China. Electronic address:
Methotrexate (MTX) is a cytotoxic drug widely used in the treatment of tumors, autoimmune diseases and severe asthma. jen00883This drug has been frequently detected in the aquatic environment with concentrations up to μg/L levels. The MTX present in environmental water might be transformed and removed during chlorination disinfection treatment.
View Article and Find Full Text PDFSpecies differences of organic anion transporters involved in the renal uptake of 4-amino-3-chlorophenyl hydrogen sulfate, a metabolite of resatorvid, between rats and dogs.
Biopharm Drug Dispos
May 2013
Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Co. Ltd, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, Japan. Takeuchi_
Previous studies on the metabolic fate of resatorvid (TAK-242) have shown that species differences in the pharmacokinetics of 4-amino-3-chlorophenyl hydrogen sulfate (M-III), a metabolite of TAK-242, between rats and dogs are mainly attributable to the urinary excretion process. In the present study, the renal uptake mechanism of M-III was investigated using kidney slices and Xenopus laevis oocytes expressing rat organic anion transporter 1 (rOat1; Slc22a6) and rOat3 (Slc22a8). The uptake of p-aminohippuric acid (PAH), a substrate for Oats, by kidney slices from rats and dogs increased at 37 °C and M-III inhibited the uptake.
View Article and Find Full Text PDFFluroxypyr biodegradation in soils by multiple factors.
Environ Monit Assess
April 2011
Department of Applied Chemistry, College of Science, Nanjing Agricultural University, Nanjing, 210095, China.
Fluroxypyr (4-amino-3,5-dichloro-6-fluoro-2-pyridinyl-1-methylheptyl ester) is a widely used herbicide for controlling weeds, fungi, and insects. However, extensive use of the herbicide has led to its high accumulation in ecosystems and contamination to soils and crops. Environmental behaviors and fate of herbicides are dependent on many physiochemical and biological factors.
View Article and Find Full Text PDFAssessment of the Fate of Two Herbicides in a Wyoming Rangeland Soil: Column Studies.
J Environ Qual
September 1994
Dep. of Civil and Architectural Eng., P.O. Box 3295, Univ. of Wyoming, Laramie, WY, 82071-3295.
Extensive use of dicamba (2-methoxy-3,6-dichlorobenzoic acid) and picloram (4-amino-3,5,6-trichloropicolinic acid) in arid Wyoming, along with large volumes of irrigation water used in some areas, has created a concern for the potential contamination of surface and groundwaters by these herbicides. Persistence and mobility of dicamba and picloram were investigated in a Wyoming rangeland soil using batch adsorption and soil column studies. The objectives of this study were to characterize soil chemical and physical properties that affect herbicide transport, examine herbicide sorption, model herbicide movement, and estimate degradation rate constants.
View Article and Find Full Text PDFThe fate of picloram (4-amino-3,5,6-trichloropicolinic acid), an active ingredient in TORDON brand herbicides, was defined in 6 healthy male volunteers following single po doses of 5.0 and 0.5 mg/kg, and a dermal dose of 2.
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