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| http://dx.doi.org/10.4161/cc.26976 | DOI Listing |
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Replisomal coupling between the α-Pol III core and the τ-subunit of the clamp loader complex (CLC) are essential for genomic integrity in E. coli.
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January 2025
Department of Chemistry and Biochemistry, Baylor University, Waco, Texas, 76798-7348, USA. Electronic address:
Coupling interactions between the alpha (α) subunit of the polymerase III core (α-Pol III core) and the tau (τ) subunit of the clamp loader complex (τ-CLC) are vital for efficient and rapid DNA replication in Escherichia coli (E. coli). Specific and targeted mutations in the C-terminal τ-interaction region of the Pol III α-subunit disrupted efficient coupled rolling circle DNA synthesis in vitro and caused significant genomic defects in CRISPR-Cas9 dnaE edited cell strains.
View Article and Find Full Text PDFNuclear N-WASP Induces Actin Polymerization in the Nucleus with Cortactin as an Essential Factor.
Cells
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Biotech Research and Innovation Center (BRIC), University of Copenhagen, Ole Maaløes Vej5, 2200 Copenhagen, Denmark.
Nuclear actin polymerization was reported to control different nuclear processes, but its regulation is poorly understood. Here, we show that N-WASP can trigger the formation of nuclear N-WASP/F-actin nodules. While a cancer hotspot mutant of N-WASP lacking the VCA domain (V418fs) had a dominant negative function on nuclear F-actin, an even shorter truncation mutant found in melanoma (R128*) strongly promoted nuclear actin polymerization.
View Article and Find Full Text PDFCoordinated expression of replication-dependent (RD) histones genes occurs within the Histone Locus Body (HLB) during S phase, but the molecular steps in transcription that are cell cycle regulated are unknown. We report that RNA Pol II promotes HLB formation and is enriched in the HLB outside of S phase, including G1-arrested cells that do not transcribe RD histone genes. In contrast, the transcription elongation factor Spt6 is enriched in HLBs only during S phase.
View Article and Find Full Text PDFEfficacy of feeding spray-dried porcine plasma to turkeys during brooding on performance to market age.
Pol J Vet Sci
September 2024
APC Europe, SLU, Avda. Sant Julià 246-258, P.I. El Congost, 08403, Granollers, Spain.
The effect of feeding spray dried porcine plasma (SDPP) to male turkeys during the first 4 weeks of life was evaluated at 20 weeks of age. A total of 648 male Hybrid Converter day-old turkeys were divided into two groups of 9 replicate pens of 36 birds each, and fed a commercial-type program of 7 diet phases. In phase 1 birds were fed a corn-soybean meal Control diet for 4 weeks, or a diet with 2% SDPP of similar nutrient density.
View Article and Find Full Text PDFEffect of dietary supplementation of jujube fruit (Ziziphus jujuba) powder on performance, some biochemical parameters, and egg quality in quails (Coturnix coturnix japonica).
Pol J Vet Sci
June 2024
Elazıg Veterinary Control Institute, Republic of Turkey Ministry of Agriculture and Forestry, 23200, Elazig, Turkey.
This study aimed to evaluate the effects of different dietary supplementation levels with jujube fruit powder on the performance, biochemical parameters, and egg quality characteristics of laying quails. A total of 60 quails (45 days old) were randomly assigned to treatments with different levels of jujube fruit powder: a basal diet (control) and diets supplemented with 5 g/kg (T1), 10 g/kg (T2), with five replicates per treatment (20 quails/treatment and four quails/replicate). The differences between 1-15 and 16-30 days for feed intake (p<0.
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