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Most brain studies of Parkinson's disease (PD) focus on patients who are already taking antiparkinsonian medication. This makes it difficult to isolate the effects of disease from those of treatment. We review magnetic resonance imaging evidence supporting the hypothesis that early-stage untreated PD patients have structural and functional abnormalities in the brain, some of which are related to motor symptoms.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885158 | PMC |
| http://dx.doi.org/10.1249/JES.0000000000000003 | DOI Listing |
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