Clear cell myoepithelioma arising from the minor salivary glands of hard palate is a rare entity. Most of the cases of palatal myoepitheliomas reported so far are either plasmacytoid or spindle cell type. Our literature search revealed only one case report of clear cell myoepithelioma of the palate. We report a case in a 21-year-old female who presented to us with a non-ulcerating, painless firm swell.ing of the left side of the hard palate. The tumor was excised with a healthy rim of surrounding tissue. Immunohistochemistry was performed on formalin-fixed and paraffin-embedded tissue with a panel of immunohistochemical markers. Tumor cells showed positivity for S100, cytokeratin and Muscle specific actin. Histological and immunohistochemical analyses revealed the tumor to be a myoepithelioma of the clear cell variety.
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http://dx.doi.org/10.5144/0256-4947.2013.492 | DOI Listing |
Acta Physiol (Oxf)
February 2025
Department of Physiology, Pharmacology and Toxicology, West Virginia University, Morgantown, West Virginia, USA.
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View Article and Find Full Text PDFBenign prostatic hyperplasia (BPH) is among the most common age-associated diseases in men; however, the contribution of age-related changes in immune cells to BPH is not clear. The current study determined that an age-associated CD8 T cell subset (Taa) with high Granzyme K ( ) and low Granzyme B ( ) gene expression infiltrate aged human prostates and positively correlate with International Prostate Symptom Score (IPSS). A velocity analysis indicated that CD8 T cell differentiation is altered in large BPH prostates compared to small age-matched prostates, favoring Taa accumulation.
View Article and Find Full Text PDFGene expression is coordinated by a multitude of transcription factors (TFs), whose binding to the genome is directed through multiple interconnected epigenetic signals, including chromatin accessibility and histone modifications. These complex networks have been shown to be disrupted during aging, disease, and cancer. However, profiling these networks across diverse cell types and states has been limited due to the technical constraints of existing methods for mapping DNA:Protein interactions in single cells.
View Article and Find Full Text PDFTaiwan J Ophthalmol
December 2024
Singapore National Eye Centre, Singapore Eye Research Institute, Singapore.
Inherited retinal degeneration (IRD) is a heterogeneous group of genetic disorders of variable onset and severity, with vision loss being a common endpoint in most cases. More than 50 distinct IRD phenotypes and over 280 causative genes have been described. Establishing a clinical phenotype for patients with IRD is particularly challenging due to clinical variability even among patients with similar genotypes.
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