AI Article Synopsis
- This study examines the impact of genetic variations (SNPs) in the DDAH1, DDAH2, and AGXT2 genes on levels of two substances, ADMA and SDMA, and their links to cardiovascular disease (CVD) in older adults with type 2 diabetes.
- Researchers assessed 783 participants' plasma dimethylarginines and followed them for 4 years to track CVD events, noting significant associations of ADMA levels with sex and specific SNPs in DDAH1, while SDMA levels were linked to AGXT2 SNPs.
- Despite these associations, the study concluded that neither ADMA nor SDMA had a clear connection to new occurrences of CVD, and the
Article Abstract
Objective: To investigate determinants of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), including single nucleotide polymorphisms (SNPs), in the DDAH1, DDAH2, and AGXT2 genes and their associations with prevalent and incident cardiovascular disease (CVD) in older adults with type 2 diabetes mellitus.
Research Design And Methods: Prevalent CVD was assessed in men and women aged 60-75 years with type 2 diabetes as part of the Edinburgh Type 2 Diabetes Study (ET2DS), and the participants were prospectively followed up for 4 years for incident CVD. Dimethylarginines were measured in 783 of these subjects, and genotyping for tag SNPs in the DDAH1, DDAH2, and AGXT2 genes was performed in 935 subjects.
Results: Plasma ADMA levels were significantly associated with SNPs in DDAH1 (top SNP rs1554597; P = 9.0E-09), while SDMA levels were associated with SNPs in AGXT2 (top SNP rs28305; P = 1.3E-04). Significant, independent determinants of plasma ADMA were sex, L-arginine, creatinine, fasting glucose, and rs1554597 (all P < 0.05; combined R(2) = 0.213). Determinants of SDMA were age, sex, creatinine, L-arginine, diabetes duration, prevalent CVD, and rs28305 (all P < 0.05; combined R(2) = 0.425). Neither dimethylarginine was associated with incident CVD. None of the investigated SNPs were associated with overall CVD, although subgroup analysis revealed a significant association of AGXT2 rs28305 with intermittent claudication.
Conclusions: Our study in a well-characterized population with type 2 diabetes does not support reported associations or causal relationship between ADMA and features of diabetes or CVD.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2337/dc13-0546 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Role of gliflozins on hepatocellular carcinoma progression: a systematic synthesis of preclinical and clinical evidence.
Expert Opin Drug Saf
December 2024
Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Introduction: The risk of HCC is twice as high in diabetic patients compared to non-diabetic ones, suggesting that diabetes advances carcinogenesis in the liver through a variety of mechanisms. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have been shown to improve liver outcomes, emerging as promising agents to treat hepatocellular carcinoma (HCC) in patients with type 2 diabetes mellitus (T2DM).
Methods: We searched PubMed and Scopus databases for articles presenting an association between SGLT2is and HCC to explore the putative mechanisms of action underlying the anti-proliferative activity of SGLT2is.
Jessner Lymphocytic Infiltrate in Anti-HMGCR Myopathy.
JAMA Dermatol
December 2024
Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Risk of acute kidney injury after contrast-enhanced MRI examinations in a pediatric population.
Eur Radiol
December 2024
Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Objectives: To investigate the associations between gadolinium-based contrast agent (GBCA) administration and the occurrence of acute kidney injury (AKI) in pediatric patients, and to determine the risks associated with AKI.
Materials And Methods: This retrospective study was conducted on pediatric patients who underwent contrast-enhanced or unenhanced MRI between January 1st, 2015, and June 30th, 2021. Examinations were included if they had data on height and serum creatinine levels within 3 months before and 2 days after the examinations.
Comment on "Effects of Traditional Chinese Exercises on Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials".
Sports Med
December 2024
Blood Purification Center, Longhua Hospital Shanghai University of Traditional Chinese Medicine, South Wanping Road No. 725, Shanghai, China.
Discontinuation of biologic and target-specific therapy in patients with rheumatoid arthritis: a retrospective cohort study.
Rheumatol Int
December 2024
Clinic of Rheumatology, UMHAT "Kaspela", Medical University of Plovaffiliation, 64 Sofia str, Plovaffiliation, 4000, Bulgaria.
Background: Rheumatoid arthritis is a progressive disease that requires continuous treatment. Despite the excellent results, treatment with biologics and target-specific disease-modifying anti-rheumatic drugs often has to be interrupted due to insufficient therapeutic effectiveness, toxicity, or side effects.
Purpose: The purpose of this study is to identify the reasons and factors influencing treatment discontinuation with biologic and target-specific drugs among the Bulgarian patients with rheumatoid arthritis.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!